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A path forward in the debate over health impacts of endocrine disrupting chemicals.

Environmental health : a global access science source

Zoeller RT, Bergman Å, Becher G, Bjerregaard P, Bornman R, Brandt I, Iguchi T, Jobling S, Kidd KA, Kortenkamp A, Skakkebaek NE, Toppari J, Vandenberg LN.
PMID: 25533907
Environ Health. 2014 Dec 22;13:118. doi: 10.1186/1476-069X-13-118.

Several recent publications reflect debate on the issue of "endocrine disrupting chemicals" (EDCs), indicating that two seemingly mutually exclusive perspectives are being articulated separately and independently. Considering this, a group of scientists with expertise in basic science, medicine and...

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Zoeller RT, Bergman Å, Becher G, et al. A path forward in the debate over health impacts of endocrine disrupting chemicals. Environ Health. 2014;13:118doi: 10.1186/1476-069X-13-118.
Zoeller, R. T., Bergman, �. �., Becher, G., Bjerregaard, P., Bornman, R., Brandt, I., Iguchi, T., Jobling, S., Kidd, K. A., Kortenkamp, A., Skakkebaek, N. E., Toppari, J., & Vandenberg, L. N. (2014). A path forward in the debate over health impacts of endocrine disrupting chemicals. Environmental health : a global access science source, 13118. https://doi.org/10.1186/1476-069X-13-118
Zoeller, R Thomas, et al. "A path forward in the debate over health impacts of endocrine disrupting chemicals." Environmental health : a global access science source vol. 13 (2014): 118. doi: https://doi.org/10.1186/1476-069X-13-118
Zoeller RT, Bergman Å, Becher G, Bjerregaard P, Bornman R, Brandt I, Iguchi T, Jobling S, Kidd KA, Kortenkamp A, Skakkebaek NE, Toppari J, Vandenberg LN. A path forward in the debate over health impacts of endocrine disrupting chemicals. Environ Health. 2014 Dec 22;13:118. doi: 10.1186/1476-069X-13-118. PMID: 25533907; PMCID: PMC4298083.
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Does more than one biopsy of the contralateral testis in men with a germ cell tumor add value?.

Nature clinical practice. Urology

Hoei-Hansen CE, Rajpert-De Meyts E, Daugaard G, Rorth M, Jorgensen N, Skakkebaek NE.
PMID: 17955048
Nat Clin Pract Urol. 2007 Dec;4(12):652-3. doi: 10.1038/ncpuro0964. Epub 2007 Oct 23.

No abstract available.

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Hoei-Hansen CE, Rajpert-De Meyts E, Daugaard G, et al. Does more than one biopsy of the contralateral testis in men with a germ cell tumor add value?. Nat Clin Pract Urol. 2007;4(12):652-3doi: 10.1038/ncpuro0964.
Hoei-Hansen, C. E., Rajpert-De Meyts, E., Daugaard, G., Rorth, M., Jorgensen, N., & Skakkebaek, N. E. (2007). Does more than one biopsy of the contralateral testis in men with a germ cell tumor add value?. Nature clinical practice. Urology, 4(12), 652-3. https://doi.org/10.1038/ncpuro0964
Hoei-Hansen, Christina E, et al. "Does more than one biopsy of the contralateral testis in men with a germ cell tumor add value?." Nature clinical practice. Urology vol. 4,12 (2007): 652-3. doi: https://doi.org/10.1038/ncpuro0964
Hoei-Hansen CE, Rajpert-De Meyts E, Daugaard G, Rorth M, Jorgensen N, Skakkebaek NE. Does more than one biopsy of the contralateral testis in men with a germ cell tumor add value?. Nat Clin Pract Urol. 2007 Dec;4(12):652-3. doi: 10.1038/ncpuro0964. Epub 2007 Oct 23. PMID: 17955048.
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The Possible Impact of Antenatal Exposure to Ubiquitous Phthalates Upon Male Reproductive Function at 20 Years of Age.

Frontiers in endocrinology

Hart RJ, Frederiksen H, Doherty DA, Keelan JA, Skakkebaek NE, Minaee NS, McLachlan R, Newnham JP, Dickinson JE, Pennell CE, Norman RJ, Main KM.
PMID: 29922230
Front Endocrinol (Lausanne). 2018 Jun 04;9:288. doi: 10.3389/fendo.2018.00288. eCollection 2018.

Phthalates are ubiquitous environmental endocrine-disrupting chemicals suspected to interfere with developmental androgen action leading to adverse effects on male reproductive function. Prenatal exposure studies in rodents show cryptorchidism, hypospadias and reduced testicular volume (TV), testosterone and anogenital distance in...

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Hart RJ, Frederiksen H, Doherty DA, et al. The Possible Impact of Antenatal Exposure to Ubiquitous Phthalates Upon Male Reproductive Function at 20 Years of Age. Front Endocrinol (Lausanne). 2018;9:288doi: 10.3389/fendo.2018.00288.
Hart, R. J., Frederiksen, H., Doherty, D. A., Keelan, J. A., Skakkebaek, N. E., Minaee, N. S., McLachlan, R., Newnham, J. P., Dickinson, J. E., Pennell, C. E., Norman, R. J., & Main, K. M. (2018). The Possible Impact of Antenatal Exposure to Ubiquitous Phthalates Upon Male Reproductive Function at 20 Years of Age. Frontiers in endocrinology, 9288. https://doi.org/10.3389/fendo.2018.00288
Hart, Roger J, et al. "The Possible Impact of Antenatal Exposure to Ubiquitous Phthalates Upon Male Reproductive Function at 20 Years of Age." Frontiers in endocrinology vol. 9 (2018): 288. doi: https://doi.org/10.3389/fendo.2018.00288
Hart RJ, Frederiksen H, Doherty DA, Keelan JA, Skakkebaek NE, Minaee NS, McLachlan R, Newnham JP, Dickinson JE, Pennell CE, Norman RJ, Main KM. The Possible Impact of Antenatal Exposure to Ubiquitous Phthalates Upon Male Reproductive Function at 20 Years of Age. Front Endocrinol (Lausanne). 2018 Jun 04;9:288. doi: 10.3389/fendo.2018.00288. eCollection 2018. PMID: 29922230; PMCID: PMC5996240.
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Author Correction: Characterisation and localisation of the endocannabinoid system components in the adult human testis.

Scientific reports

Nielsen JE, Rolland AD, Meyts ER, Janfelt C, Jørgensen A, Winge SB, Kristensen DM, Juul A, Chalmel F, Jégou B, Skakkebaek NE.
PMID: 31965051
Sci Rep. 2020 Jan 22;10(1):1267. doi: 10.1038/s41598-020-58153-w.

An amendment to this paper has been published and can be accessed via a link at the top of the paper.

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Nielsen JE, Rolland AD, Meyts ER, et al. Author Correction: Characterisation and localisation of the endocannabinoid system components in the adult human testis. Sci Rep. 2020;10(1):1267doi: 10.1038/s41598-020-58153-w.
Nielsen, J. E., Rolland, A. D., Meyts, E. R., Janfelt, C., Jørgensen, A., Winge, S. B., Kristensen, D. M., Juul, A., Chalmel, F., Jégou, B., & Skakkebaek, N. E. (2020). Author Correction: Characterisation and localisation of the endocannabinoid system components in the adult human testis. Scientific reports, 10(1), 1267. https://doi.org/10.1038/s41598-020-58153-w
Nielsen, John E, et al. "Author Correction: Characterisation and localisation of the endocannabinoid system components in the adult human testis." Scientific reports vol. 10,1 (2020): 1267. doi: https://doi.org/10.1038/s41598-020-58153-w
Nielsen JE, Rolland AD, Meyts ER, Janfelt C, Jørgensen A, Winge SB, Kristensen DM, Juul A, Chalmel F, Jégou B, Skakkebaek NE. Author Correction: Characterisation and localisation of the endocannabinoid system components in the adult human testis. Sci Rep. 2020 Jan 22;10(1):1267. doi: 10.1038/s41598-020-58153-w. PMID: 31965051; PMCID: PMC6974603.
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Paracetamol use during pregnancy - a call for precautionary action.

Nature reviews. Endocrinology

Bauer AZ, Swan SH, Kriebel D, Liew Z, Taylor HS, Bornehag CG, Andrade AM, Olsen J, Jensen RH, Mitchell RT, Skakkebaek NE, Jégou B, Kristensen DM.
PMID: 34556849
Nat Rev Endocrinol. 2021 Dec;17(12):757-766. doi: 10.1038/s41574-021-00553-7. Epub 2021 Sep 23.

Paracetamol (N-acetyl-p-aminophenol (APAP), otherwise known as acetaminophen) is the active ingredient in more than 600 medications used to relieve mild to moderate pain and reduce fever. APAP is widely used by pregnant women as governmental agencies, including the FDA...

Cite
Bauer AZ, Swan SH, Kriebel D, et al. Paracetamol use during pregnancy - a call for precautionary action. Nat Rev Endocrinol. 2021;17(12):757-766doi: 10.1038/s41574-021-00553-7.
Bauer, A. Z., Swan, S. H., Kriebel, D., Liew, Z., Taylor, H. S., Bornehag, C. G., Andrade, A. M., Olsen, J., Jensen, R. H., Mitchell, R. T., Skakkebaek, N. E., Jégou, B., & Kristensen, D. M. (2021). Paracetamol use during pregnancy - a call for precautionary action. Nature reviews. Endocrinology, 17(12), 757-766. https://doi.org/10.1038/s41574-021-00553-7
Bauer, Ann Z, et al. "Paracetamol use during pregnancy - a call for precautionary action." Nature reviews. Endocrinology vol. 17,12 (2021): 757-766. doi: https://doi.org/10.1038/s41574-021-00553-7
Bauer AZ, Swan SH, Kriebel D, Liew Z, Taylor HS, Bornehag CG, Andrade AM, Olsen J, Jensen RH, Mitchell RT, Skakkebaek NE, Jégou B, Kristensen DM. Paracetamol use during pregnancy - a call for precautionary action. Nat Rev Endocrinol. 2021 Dec;17(12):757-766. doi: 10.1038/s41574-021-00553-7. Epub 2021 Sep 23. PMID: 34556849; PMCID: PMC8580820.
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Early detection of testicular cancer: An introduction.

International journal of andrology

Skakkebaek NE.
PMID: 29112239
Int J Androl. 1981 Mar;4:11-13. doi: 10.1111/j.1365-2605.1981.tb00644.x.

No abstract available.

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Skakkebaek NE. Early detection of testicular cancer: An introduction. Int J Androl. 1981;4:11-13doi: 10.1111/j.1365-2605.1981.tb00644.x.
Skakkebaek, N. E. (1981). Early detection of testicular cancer: An introduction. International journal of andrology, 411-13. https://doi.org/10.1111/j.1365-2605.1981.tb00644.x
Skakkebaek, Niels E. "Early detection of testicular cancer: An introduction." International journal of andrology vol. 4 (1981): 11-13. doi: https://doi.org/10.1111/j.1365-2605.1981.tb00644.x
Skakkebaek NE. Early detection of testicular cancer: An introduction. Int J Androl. 1981 Mar;4:11-13. doi: 10.1111/j.1365-2605.1981.tb00644.x. PMID: 29112239.
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Carcinoma-in-situ of the testis and invasive growth of different types of germ cell tumours. A revised germ cell theory.

International journal of andrology

Skakkebaek NE, Berthelsen JG.
PMID: 29112252
Int J Androl. 1981 Mar;4:26-33. doi: 10.1111/j.1365-2605.1981.tb00647.x.

The hypothesis is proposed that seminomas and non-seminomas are histogenetically closely related and both types of germ cell tumours may originate from a common precursor cell: namely the germ cell showing the carcinoma-in-situ pattern. However, it is suggested that...

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Skakkebaek NE, Berthelsen JG. Carcinoma-in-situ of the testis and invasive growth of different types of germ cell tumours. A revised germ cell theory. Int J Androl. 1981;4:26-33doi: 10.1111/j.1365-2605.1981.tb00647.x.
Skakkebaek, N. E., & Berthelsen, J. G. (1981). Carcinoma-in-situ of the testis and invasive growth of different types of germ cell tumours. A revised germ cell theory. International journal of andrology, 426-33. https://doi.org/10.1111/j.1365-2605.1981.tb00647.x
Skakkebaek, Niels E, and Berthelsen, Jørgen G. "Carcinoma-in-situ of the testis and invasive growth of different types of germ cell tumours. A revised germ cell theory." International journal of andrology vol. 4 (1981): 26-33. doi: https://doi.org/10.1111/j.1365-2605.1981.tb00647.x
Skakkebaek NE, Berthelsen JG. Carcinoma-in-situ of the testis and invasive growth of different types of germ cell tumours. A revised germ cell theory. Int J Androl. 1981 Mar;4:26-33. doi: 10.1111/j.1365-2605.1981.tb00647.x. PMID: 29112252.
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Paracetamol use during pregnancy - a call for precautionary action.

Nature reviews. Endocrinology

Bauer AZ, Swan SH, Kriebel D, Liew Z, Taylor HS, Bornehag CG, Andrade AM, Olsen J, Jensen RH, Mitchell RT, Skakkebaek NE, Jégou B, Kristensen DM.
PMID: 34556849
Nat Rev Endocrinol. 2021 Dec;17(12):757-766. doi: 10.1038/s41574-021-00553-7. Epub 2021 Sep 23.

Paracetamol (N-acetyl-p-aminophenol (APAP), otherwise known as acetaminophen) is the active ingredient in more than 600 medications used to relieve mild to moderate pain and reduce fever. APAP is widely used by pregnant women as governmental agencies, including the FDA...

Cite
Bauer AZ, Swan SH, Kriebel D, et al. Paracetamol use during pregnancy - a call for precautionary action. Nat Rev Endocrinol. 2021;17(12):757-766doi: 10.1038/s41574-021-00553-7.
Bauer, A. Z., Swan, S. H., Kriebel, D., Liew, Z., Taylor, H. S., Bornehag, C. G., Andrade, A. M., Olsen, J., Jensen, R. H., Mitchell, R. T., Skakkebaek, N. E., Jégou, B., & Kristensen, D. M. (2021). Paracetamol use during pregnancy - a call for precautionary action. Nature reviews. Endocrinology, 17(12), 757-766. https://doi.org/10.1038/s41574-021-00553-7
Bauer, Ann Z, et al. "Paracetamol use during pregnancy - a call for precautionary action." Nature reviews. Endocrinology vol. 17,12 (2021): 757-766. doi: https://doi.org/10.1038/s41574-021-00553-7
Bauer AZ, Swan SH, Kriebel D, Liew Z, Taylor HS, Bornehag CG, Andrade AM, Olsen J, Jensen RH, Mitchell RT, Skakkebaek NE, Jégou B, Kristensen DM. Paracetamol use during pregnancy - a call for precautionary action. Nat Rev Endocrinol. 2021 Dec;17(12):757-766. doi: 10.1038/s41574-021-00553-7. Epub 2021 Sep 23. PMID: 34556849; PMCID: PMC8580820.
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Paracetamol use during pregnancy - a call for precautionary action.

Nature reviews. Endocrinology

Bauer AZ, Swan SH, Kriebel D, Liew Z, Taylor HS, Bornehag CG, Andrade AM, Olsen J, Jensen RH, Mitchell RT, Skakkebaek NE, Jégou B, Kristensen DM.
PMID: 34556849
Nat Rev Endocrinol. 2021 Dec;17(12):757-766. doi: 10.1038/s41574-021-00553-7. Epub 2021 Sep 23.

Paracetamol (N-acetyl-p-aminophenol (APAP), otherwise known as acetaminophen) is the active ingredient in more than 600 medications used to relieve mild to moderate pain and reduce fever. APAP is widely used by pregnant women as governmental agencies, including the FDA...

Cite
Bauer AZ, Swan SH, Kriebel D, et al. Paracetamol use during pregnancy - a call for precautionary action. Nat Rev Endocrinol. 2021;17(12):757-766doi: 10.1038/s41574-021-00553-7.
Bauer, A. Z., Swan, S. H., Kriebel, D., Liew, Z., Taylor, H. S., Bornehag, C. G., Andrade, A. M., Olsen, J., Jensen, R. H., Mitchell, R. T., Skakkebaek, N. E., Jégou, B., & Kristensen, D. M. (2021). Paracetamol use during pregnancy - a call for precautionary action. Nature reviews. Endocrinology, 17(12), 757-766. https://doi.org/10.1038/s41574-021-00553-7
Bauer, Ann Z, et al. "Paracetamol use during pregnancy - a call for precautionary action." Nature reviews. Endocrinology vol. 17,12 (2021): 757-766. doi: https://doi.org/10.1038/s41574-021-00553-7
Bauer AZ, Swan SH, Kriebel D, Liew Z, Taylor HS, Bornehag CG, Andrade AM, Olsen J, Jensen RH, Mitchell RT, Skakkebaek NE, Jégou B, Kristensen DM. Paracetamol use during pregnancy - a call for precautionary action. Nat Rev Endocrinol. 2021 Dec;17(12):757-766. doi: 10.1038/s41574-021-00553-7. Epub 2021 Sep 23. PMID: 34556849; PMCID: PMC8580820.
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Paracetamol use during pregnancy - a call for precautionary action.

Nature reviews. Endocrinology

Bauer AZ, Swan SH, Kriebel D, Liew Z, Taylor HS, Bornehag CG, Andrade AM, Olsen J, Jensen RH, Mitchell RT, Skakkebaek NE, Jégou B, Kristensen DM.
PMID: 34556849
Nat Rev Endocrinol. 2021 Dec;17(12):757-766. doi: 10.1038/s41574-021-00553-7. Epub 2021 Sep 23.

Paracetamol (N-acetyl-p-aminophenol (APAP), otherwise known as acetaminophen) is the active ingredient in more than 600 medications used to relieve mild to moderate pain and reduce fever. APAP is widely used by pregnant women as governmental agencies, including the FDA...

Cite
Bauer AZ, Swan SH, Kriebel D, et al. Paracetamol use during pregnancy - a call for precautionary action. Nat Rev Endocrinol. 2021;17(12):757-766doi: 10.1038/s41574-021-00553-7.
Bauer, A. Z., Swan, S. H., Kriebel, D., Liew, Z., Taylor, H. S., Bornehag, C. G., Andrade, A. M., Olsen, J., Jensen, R. H., Mitchell, R. T., Skakkebaek, N. E., Jégou, B., & Kristensen, D. M. (2021). Paracetamol use during pregnancy - a call for precautionary action. Nature reviews. Endocrinology, 17(12), 757-766. https://doi.org/10.1038/s41574-021-00553-7
Bauer, Ann Z, et al. "Paracetamol use during pregnancy - a call for precautionary action." Nature reviews. Endocrinology vol. 17,12 (2021): 757-766. doi: https://doi.org/10.1038/s41574-021-00553-7
Bauer AZ, Swan SH, Kriebel D, Liew Z, Taylor HS, Bornehag CG, Andrade AM, Olsen J, Jensen RH, Mitchell RT, Skakkebaek NE, Jégou B, Kristensen DM. Paracetamol use during pregnancy - a call for precautionary action. Nat Rev Endocrinol. 2021 Dec;17(12):757-766. doi: 10.1038/s41574-021-00553-7. Epub 2021 Sep 23. PMID: 34556849; PMCID: PMC8580820.
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Endocrine-disrupting chemicals and public health protection: a statement of principles from The Endocrine Society.

Endocrinology

Zoeller RT, Brown TR, Doan LL, Gore AC, Skakkebaek NE, Soto AM, Woodruff TJ, Vom Saal FS.
PMID: 22733974
Endocrinology. 2012 Sep;153(9):4097-110. doi: 10.1210/en.2012-1422. Epub 2012 Jun 25.

An endocrine-disrupting chemical (EDC) is an exogenous chemical, or mixture of chemicals, that can interfere with any aspect of hormone action. The potential for deleterious effects of EDC must be considered relative to the regulation of hormone synthesis, secretion,...

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Zoeller RT, Brown TR, Doan LL, et al. Endocrine-disrupting chemicals and public health protection: a statement of principles from The Endocrine Society. Endocrinology. 2012;153(9):4097-110doi: 10.1210/en.2012-1422.
Zoeller, R. T., Brown, T. R., Doan, L. L., Gore, A. C., Skakkebaek, N. E., Soto, A. M., Woodruff, T. J., & Vom Saal, F. S. (2012). Endocrine-disrupting chemicals and public health protection: a statement of principles from The Endocrine Society. Endocrinology, 153(9), 4097-110. https://doi.org/10.1210/en.2012-1422
Zoeller, R Thomas, et al. "Endocrine-disrupting chemicals and public health protection: a statement of principles from The Endocrine Society." Endocrinology vol. 153,9 (2012): 4097-110. doi: https://doi.org/10.1210/en.2012-1422
Zoeller RT, Brown TR, Doan LL, Gore AC, Skakkebaek NE, Soto AM, Woodruff TJ, Vom Saal FS. Endocrine-disrupting chemicals and public health protection: a statement of principles from The Endocrine Society. Endocrinology. 2012 Sep;153(9):4097-110. doi: 10.1210/en.2012-1422. Epub 2012 Jun 25. PMID: 22733974; PMCID: PMC3423612.
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Microspectrophotometric DNA measurements of carcinoma-in-situ germ cells in the testis.

International journal of andrology

Müller J, Skakkebaek NE.
PMID: 29112246
Int J Androl. 1981 Mar;4:211-220. doi: 10.1111/j.1365-2605.1981.tb00680.x.

Early detection of premalignant changes of the testis in at-risk groups seems to be of considerable significance. Hitherto the diagnosis of carcinoma-in-situ testis has been based upon conventional histological techniques. A microspec-trophotometric study of the DNA content in Feulgen...

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Müller J, Skakkebaek NE. Microspectrophotometric DNA measurements of carcinoma-in-situ germ cells in the testis. Int J Androl. 1981;4:211-220doi: 10.1111/j.1365-2605.1981.tb00680.x.
Müller, J., & Skakkebaek, N. E. (1981). Microspectrophotometric DNA measurements of carcinoma-in-situ germ cells in the testis. International journal of andrology, 4211-220. https://doi.org/10.1111/j.1365-2605.1981.tb00680.x
Müller, Jørn, and Skakkebaek, Niels E. "Microspectrophotometric DNA measurements of carcinoma-in-situ germ cells in the testis." International journal of andrology vol. 4 (1981): 211-220. doi: https://doi.org/10.1111/j.1365-2605.1981.tb00680.x
Müller J, Skakkebaek NE. Microspectrophotometric DNA measurements of carcinoma-in-situ germ cells in the testis. Int J Androl. 1981 Mar;4:211-220. doi: 10.1111/j.1365-2605.1981.tb00680.x. PMID: 29112246.
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