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Showing 1 to 12 of 2343 entries
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The protective role of tacrine and donepezil in the retina of acetylcholinesterase knockout mice.

International journal of ophthalmology

Yi YM, Cai L, Shao Y, Xu M, Yi JL.
PMID: 26558196
Int J Ophthalmol. 2015 Oct 18;8(5):884-90. doi: 10.3980/j.issn.2222-3959.2015.05.06. eCollection 2015.

AIM: To determine the effect of different concentrations of the acetylcholinesterase (AChE) inhibitors tacrine and donepezil on retinal protection in AChE(+/-) mice (AChE knockout mice) of various ages.METHODS: Cultured ARPE-19 cells were treated with hydrogen peroxide (H2O2) at concentrations...

Cardioprotection and anticholinesterases in patients with Alzheimer's disease: time for reappraisal.

Dementia and geriatric cognitive disorders extra

Monacelli F, Odetti P, Sartini M, Parodi A, Brunelli C, Rosa G.
PMID: 24711813
Dement Geriatr Cogn Dis Extra. 2014 Feb 14;4(1):45-50. doi: 10.1159/000357124. eCollection 2014 Jan.

BACKGROUND/AIM: Traditional risk factors, like impaired transmitral flow in diastolic filling [vortex formation time (VFT) as echocardiographic parameter], contribute to Alzheimer's disease (AD). Moreover, we observed that acetylcholinesterase inhibitors provide a significant cardioprotection. We assessed the pathogenetic role of...

Examining the predictive accuracy of the novel 3D N-linear algebraic molecular codifications on benchmark datasets.

Journal of cheminformatics

García-Jacas CR, Contreras-Torres E, Marrero-Ponce Y, Pupo-Meriño M, Barigye SJ, Cabrera-Leyva L.
PMID: 26925168
J Cheminform. 2016 Feb 25;8:10. doi: 10.1186/s13321-016-0122-x. eCollection 2016.

BACKGROUND: Recently, novel 3D alignment-free molecular descriptors (also known as QuBiLS-MIDAS) based on two-linear, three-linear and four-linear algebraic forms have been introduced. These descriptors codify chemical information for relations between two, three and four atoms by using several (dis-)similarity...

Acetylcholinesterase inhibitor modifications: a promising strategy to delay the progression of Alzheimer's disease.

Neural regeneration research

Bhattacharya S, Montag D.
PMID: 25788916
Neural Regen Res. 2015 Jan;10(1):43-5. doi: 10.4103/1673-5374.150648.

No abstract available.

Inhibitory effect of some natural and semisynthetic phenolic lipids upon acetylcholinesterase activity.

Food chemistry

Stasiuk M, Bartosiewicz D, Kozubek A.
PMID: 26065763
Food Chem. 2008 Jun 01;108(3):996-1001. doi: 10.1016/j.foodchem.2007.12.011. Epub 2007 Dec 14.

The effect of phenolic lipids isolated from rye grains and cashew nut shell liquid (CNSL) from Anacardium occidentale and their semisynthetic derivatives on erythrocyte ghost's acetylcholinesterase activity was studied. It has been shown that all tested compounds decreased the...

Methodological framework to identify possible adverse drug reactions using population-based administrative data.

F1000Research

Sauer B, Nebeker J, Shen S, Rupper R, West S, Shinogle JA, Xu W, Lohr KN, Samore M.
PMID: 26180631
F1000Res. 2014 Oct 29;3:258. doi: 10.12688/f1000research.4816.1. eCollection 2014.

PURPOSE: We present a framework for detecting possible adverse drug reactions (ADRs) using the Utah Medicaid administrative data. We examined four classes of ADRs associated with treatment of dementia by acetylcholinesterase inhibitors (AChEIs): known reactions (gastrointestinal, psychological disturbances), potential...

Effects of Zusanli and Ashi Acupoint Electroacupuncture on Repair of Skeletal Muscle and Neuromuscular Junction in a Rabbit Gastrocnemius Contusion Model.

Evidence-based complementary and alternative medicine : eCAM

Yu ZG, Wang RG, Xiao C, Zhao JY, Shen Q, Liu SY, Xu QW, Zhang QX, Wang YT.
PMID: 27190536
Evid Based Complement Alternat Med. 2016;2016:7074563. doi: 10.1155/2016/7074563. Epub 2016 Apr 13.

Objective. To explore the effects of electroacupuncture (EA) at ST36 (EA-ST36) and at Ashi acupoints (EA-Ashi) on skeletal muscle repair. Methods. Seventy-five rabbits were randomly divided into five groups: normal, contusion, EA-Ashi, EA-ST36, and EA at Ashi acupoints and...

Delirium Accompanied by Cholinergic Deficiency and Organ Failure in a 73-Year-Old Critically Ill Patient: Physostigmine as a Therapeutic Option.

Case reports in critical care

Zujalovic B, Barth E.
PMID: 26550498
Case Rep Crit Care. 2015;2015:793015. doi: 10.1155/2015/793015. Epub 2015 Oct 13.

Delirium is a common problem in ICU patients, resulting in prolonged ICU stay and increased mortality. A cholinergic deficiency in the central nervous system is supposed to be a relevant pathophysiologic process in delirium. Acetylcholine is a major transmitter...

Effectiveness of rivastigmine on positive, negative, and cognitive symptoms of schizophrenia: a double-blind clinical trial.

Therapeutic advances in psychopharmacology

Shoja Shafti S, Azizi Khoei A.
PMID: 27721970
Ther Adv Psychopharmacol. 2016 Oct;6(5):308-316. doi: 10.1177/2045125316656334. Epub 2016 Sep 14.

BACKGROUND: Several lines of evidence suggest that the cholinergic system may be disrupted in schizophrenia and so this may contribute to the cognitive impairments of schizophrenic patients. Because such deficits do not respond to neuroleptic treatment, different approaches have...

Improvement in Long-Term Memory following Chronic Administration of Eryngium planum Root Extract in Scopolamine Model: Behavioral and Molecular Study.

Evidence-based complementary and alternative medicine : eCAM

Ozarowski M, Thiem B, Mikolajczak PL, Piasecka A, Kachlicki P, Szulc M, Kaminska E, Bogacz A, Kujawski R, Bartkowiak-Wieczorek J, Kujawska M, Jodynis-Liebert J, Budzianowski J, Kędziora I, Seremak-Mrozikiewicz A, Czerny B, Bobkiewicz-Kozłowska T.
PMID: 26483842
Evid Based Complement Alternat Med. 2015;2015:145140. doi: 10.1155/2015/145140. Epub 2015 Sep 21.

Eryngium planum L. (EP) is as a rare medicinal plant with a lot of potentials as pharmaceutical crops. The aim of our study was to assess the effect of subchronic (28-fold) administration of a 70% ethanol extract of EP...

Potential Role of Honey in Learning and Memory.

Medical sciences (Basel, Switzerland)

Othman Z, Zakaria R, Hussain NHN, Hassan A, Shafin N, Al-Rahbi B, Ahmad AH.
PMID: 29083387
Med Sci (Basel). 2015 Apr 09;3(2):3-15. doi: 10.3390/medsci3020003.

The composition and physicochemical properties of honey are variable depending on its floral source and often named according to the geographical location. The potential medicinal benefits of Tualang honey, a multifloral jungle honey found in Malaysia, have recently been...

Cognitive-Enhancing Effect of Dianthus superbus var. Longicalycinus on Scopolamine-Induced Memory Impairment in Mice.

Biomolecules & therapeutics

Weon JB, Jung YS, Ma CJ.
PMID: 27133261
Biomol Ther (Seoul). 2016 May 01;24(3):298-304. doi: 10.4062/biomolther.2015.083.

Dianthus superbus (D. superbus) is a traditional crude drug used for the treatment of urethritis, carbuncles and carcinomas. The objective of this study was to confirm the cognitive enhancing effect of D. superbus in memory impairment induced mice and...

Showing 1 to 12 of 2343 entries