Advanced Search
Display options
Filter resources
Text Availability
Article type
Publication date
Species
Language
Sex
Age
Showing 1 to 12 of 844 entries
Sorted by: Best Match Show Resources per page
Vasoconstrictor effect of Africanized honeybee (Apis mellifera L.) venom on rat aorta.

The journal of venomous animals and toxins including tropical diseases

Sousa PC, Brito TS, Freire DS, Ximenes RM, Magalhães PJ, Monteiro HS, Alves RS, Martins AM, Toyama DO, Toyama MH.
PMID: 24066982
J Venom Anim Toxins Incl Trop Dis. 2013 Sep 25;19(1):24. doi: 10.1186/1678-9199-19-24.

BACKGROUND: Apis mellifera stings are a problem for public health worldwide, particularly in Latin America due to the aggressiveness of its Africanized honeybees. Massive poisoning by A. mellifera venom (AmV) affects mainly the cardiovascular system, and several works have...

A Brief Introduction to the Transduction of Neural Activity into Fos Signal.

Development & reproduction

Chung L.
PMID: 27004262
Dev Reprod. 2015 Jun;19(2):61-7. doi: 10.12717/DR.2015.19.2.061.

The immediate early gene c-fos has long been known as a molecular marker of neural activity. The neuron's activity is transformed into intracellular calcium influx through NMDA receptors and L-type voltage sensitive calcium channels. For the transcription of c-fos,...

Antiepileptic Drugs Impair Shortening of Isolated Cardiomyocytes.

Frontiers in neurology

Hulbert J, Elger CE, Meyer R, Surges R.
PMID: 28421035
Front Neurol. 2017 Apr 03;8:133. doi: 10.3389/fneur.2017.00133. eCollection 2017.

BACKGROUND: Most antiepileptic drugs (AEDs) inhibit seizure generation by acting on voltage-dependent ion channels. Voltage-dependent sodium and calcium channels are commonly expressed in brain and heart, suggesting that AEDs may have considerable cardiodepressive effects, thereby facilitating sudden cardiac death...

Presynaptic nanodomains: a tale of two synapses.

Frontiers in cellular neuroscience

Wang LY, Augustine GJ.
PMID: 25674049
Front Cell Neurosci. 2015 Jan 26;8:455. doi: 10.3389/fncel.2014.00455. eCollection 2014.

Here we summarize the evidence from two "giant" presynaptic terminals-the squid giant synapse and the mammalian calyx of Held-supporting the involvement of nanodomain calcium signals in triggering of neurotransmitter release. At the squid synapse, there are three main lines...

Autoimmune encephalopathy and drug refractory seizures with the presence of two autoantibodies specific for the neuronal cell surface.

Epilepsy & behavior case reports

Al-Ajlan FS, Althobiti A, Baz S, Al-Attas A.
PMID: 25667907
Epilepsy Behav Case Rep. 2014 Nov 27;2:199-202. doi: 10.1016/j.ebcr.2014.06.002. eCollection 2014.

BACKGROUND: An increasing number of autoantibodies are being described in epilepsy and other seizure-related disorders. A pathogenic role of autoantibodies in epilepsy has been suggested based on observations of the efficacy of immunotherapy.OBJECTIVE: This study aimed to report a...

Functional Effects of Alagebrium (ALT-711)-Isolated Rat Carotid Artery.

The Eurasian journal of medicine

Toprak C, Sirmagul B, Yigitaslan S.
PMID: 29123442
Eurasian J Med. 2017 Oct;49(3):188-192. doi: 10.5152/eurasianjmed.2017.17046.

OBJECTIVE: In our study, the effects of glycosylated protein cross-link breaker, alagebrium was investigated on isolated rat carotid artery using myography. Alagebrium showed vasodilator effect on carotid artery rings; particularly, this effect was significantly increased in endothelium-intact rings.MATERIALS AND...

Calcium channel α2δ1 subunit as a novel biomarker for diagnosis of hepatocellular carcinoma.

Cancer biology & medicine

Amhimmid Badr S, Waheeb Fahmi M, Mahmoud Nomir M, Mohammad El-Shishtawy M.
PMID: 29545968
Cancer Biol Med. 2018 Feb;15(1):52-60. doi: 10.20892/j.issn.2095-3941.2017.0167.

OBJECTIVE: Hepatocellular carcinoma (HCC) is the fifth most common malignancy worldwide. The identification of new simple, inexpensive and highly accurate markers for HCC diagnosis and screening is needed. This case-control study evaluates the role of annexin A2 and voltage-gated...

A Comparative Study on Clinical and Biochemical Parameters in Amlodipine and Cilnidipine Treated Hypertensive Patients.

Journal of clinical and diagnostic research : JCDR

Shetty K, Shetty R, Bairy L, Rao P, Kiran A, Shetty M, Deepak, Nayak V.
PMID: 28658794
J Clin Diagn Res. 2017 May;11(5):FC01-FC05. doi: 10.7860/JCDR/2017/23825.9763. Epub 2017 May 01.

INTRODUCTION: Hypertension is a major health issue worldwide. Calcium Channel Blockers (CCBs) are the most commonly used antihypertensive agents. CCBs act on voltage-dependent calcium channels and they were categorized into two subclasses, Dihydropyridine (DHP) and non-Dihydropyridine (non-DHP) derivative. Amlodipine...

Pedunculopontine arousal system physiology - Implications for insomnia.

Sleep science (Sao Paulo, Brazil)

Garcia-Rill E, Luster B, Mahaffey S, Bisagno V, Urbano FJ.
PMID: 26483950
Sleep Sci. 2015 Apr-Jun;8(2):92-9. doi: 10.1016/j.slsci.2015.06.002. Epub 2015 Jul 10.

We consider insomnia a disorder of waking rather than a disorder of sleep. This review examines the role of the reticular activating system, especially the pedunculopontine nucleus, in the symptoms of insomnia, mainly representing an overactive waking drive. We...

Preparation and preclinical evaluation of .

Indian journal of nuclear medicine : IJNM : the official journal of the Society of Nuclear Medicine, India

Firuzyar T, Jalilian AR, Aboudzadeh MR, Sadeghpour H, Shafiee-Ardestani M, Khalaj A.
PMID: 27833311
Indian J Nucl Med. 2016 Oct-Dec;31(4):267-273. doi: 10.4103/0972-3919.190797.

AIM: In order to develop a possible tracer for L-type calcium channel imaging, we here report the development of a Ga-68 amlodipine derivative for possible PET imaging.MATERIALS AND METHODS: Amlodipine DOTA conjugate was synthesized, characterized and went through calcium...

Critical Management of Severe Hypotension Caused by Amlodipine Toxicity Managed With Hyperinsulinemia/Euglycemia Therapy Supplemented With Calcium Gluconate, Intravenous Glucagon and Other Vasopressor Support: Review of Literature.

Cardiology research

Kumar K, Biyyam M, Bajantri B, Nayudu S.
PMID: 29479386
Cardiol Res. 2018 Feb;9(1):46-49. doi: 10.14740/cr646w. Epub 2018 Feb 11.

Calcium channel blocker (CCB ) overdose, whether intentional or accidental, is a common clinical scenario and can be very lethal. Conventional treatments for CCB overdose include intravenous (IV) fluids, calcium salts, dopamine, dobutamine, norepinephrine, phosphodiesterase inhibitors, and glucagon. However,...

An integrative analysis of meningioma tumors reveals the determinant genes and pathways of malignant transformation.

Frontiers in oncology

Iglesias Gómez JC, Mosquera Orgueira A.
PMID: 25003081
Front Oncol. 2014 Jun 23;4:147. doi: 10.3389/fonc.2014.00147. eCollection 2014.

Meningiomas are frequent central nervous system neoplasms, which despite their predominant benignity, show sporadically malignant behavior. Type 2 neurofibromatosis and polymorphisms in several genes have been associated with meningioma risk and are probably involved in its pathogenesis. Although GWAS...

Showing 1 to 12 of 844 entries