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Risk of cardiovascular events associated with current exposure to HIV antiretroviral therapies in a US veteran population


Joyce V, Bendavid E.
M Desai, V Joyce, E Bendavid… - Clinical Infectious …, 2015 -

Background. To characterize the association of antiretroviral drug combinations on risk of cardiovascular events. Methods. Certain antiretroviral medications for human …

[Injurious drug combinations, "drug interaction"].

Ugeskrift for laeger

Andersen AH, Pedersen A.
PMID: 5333678
Ugeskr Laeger. 1966 Aug 18;128(33):943-8.

No abstract available.

A brief history of antiretroviral therapy of HIV infection: success and challenges.

Annali dell'Istituto superiore di sanita

Palmisano L, Vella S.
PMID: 21430338
Ann Ist Super Sanita. 2011;47(1):44-8. doi: 10.4415/ANN_11_01_10.

Unprecedented efforts in the fields of biology, pharmacology and clinical care have contributed to progressively turn HIV infection from an inevitably fatal condition into a chronic manageable disease, at least in the countries where HIV infected people have full...

What is synergy? The Saariselkä agreement revisited.

Frontiers in pharmacology

Tang J, Wennerberg K, Aittokallio T.
PMID: 26388771
Front Pharmacol. 2015 Sep 01;6:181. doi: 10.3389/fphar.2015.00181. eCollection 2015.

Many biological or chemical agents when combined interact with each other and produce a synergistic response that cannot be predicted based on the single agent responses alone. However, depending on the postulated null hypothesis of non-interaction, one may end...

A Drug Combination Screen Identifies Drugs Active against Amoxicillin-Induced Round Bodies of In Vitro Borrelia burgdorferi Persisters from an FDA Drug Library.

Frontiers in microbiology

Feng J, Shi W, Zhang S, Sullivan D, Auwaerter PG, Zhang Y.
PMID: 27242757
Front Microbiol. 2016 May 23;7:743. doi: 10.3389/fmicb.2016.00743. eCollection 2016.

Although currently recommended antibiotics for Lyme disease such as doxycycline or amoxicillin cure the majority of the patients, about 10-20% of patients treated for Lyme disease may experience lingering symptoms including fatigue, pain, or joint and muscle aches. Under...

Genotoxic Damage to Glioblastoma Cells Treated with 6 MV X-Radiation in The Presence or Absence of Methoxy Estradiol, IUDR or Topotecan.

Cell journal

Eyvazzadeh N, Neshasteh-Riz A, Mahdavi SR, Mohsenifar A.
PMID: 26199910
Cell J. 2015;17(2):312-21. doi: 10.22074/cellj.2016.3738. Epub 2015 Jul 11.

OBJECTIVE: To explore the cumulative genotoxic damage to glioblastoma (GBM) cells, grown as multicellular spheroids, following exposure to 6 MV X-rays (2 Gy, 22 Gy) with or without, 2- methoxy estradiol (2ME2), iododeoxyuridine (IUDR) or topotecan (TPT), using the...

Targeted drug combinations: avant-garde oncology.

Annals of translational medicine

Dan TD, Palmer JD.
PMID: 26244146
Ann Transl Med. 2015 Jul;3(11):159. doi: 10.3978/j.issn.2305-5839.2015.06.17.

No abstract available.

Identifying Adverse Effects of HIV Drug Treatment and Associated Sentiments Using Twitter.

JMIR public health and surveillance

Adrover C, Bodnar T, Huang Z, Telenti A, Salathé M.
PMID: 27227141
JMIR Public Health Surveill. 2015 Jul 27;1(2):e7. doi: 10.2196/publichealth.4488. eCollection 2015.

BACKGROUND: Social media platforms are increasingly seen as a source of data on a wide range of health issues. Twitter is of particular interest for public health surveillance because of its public nature. However, the very public nature of...


Current colorectal cancer reports

Sreevalsan S, Safe S.
PMID: 25584043
Curr Colorectal Cancer Rep. 2013 Dec;9(4):350-357. doi: 10.1007/s11888-013-0190-5.

Several agents used for treatment of colon and other cancers induce reactive oxygen species (ROS) and this plays an important role in their anticancer activities. In addition to the well-known proapoptotic effects of ROS inducers, these compounds also decrease...

Pattern of CD4 T-lymphocyte Values in Cancer Patients on Cytotoxic Therapy.

Annals of medical and health sciences research

Madu A, Ocheni S, Ibegbulam O, Aguwa E, Madu K.
PMID: 24379998
Ann Med Health Sci Res. 2013 Oct;3(4):498-503. doi: 10.4103/2141-9248.122054.

BACKGROUND: Assessment of patients prior to cytotoxic chemotherapy usually includes absolute neutrophils count. Other cellular markers of susceptibility to infection as well as immunocompetence include the T Helper lymphocyte count. In cancer patients, decrease in these lymphocytes has been...

The Role of the Insulin/IGF System in Cancer: Lessons Learned from Clinical Trials and the Energy Balance-Cancer Link.

Frontiers in endocrinology

Bowers LW, Rossi EL, O'Flanagan CH, deGraffenried LA, Hursting SD.
PMID: 26029167
Front Endocrinol (Lausanne). 2015 May 15;6:77. doi: 10.3389/fendo.2015.00077. eCollection 2015.

Numerous epidemiological and pre-clinical studies have demonstrated that the insulin/insulin-like growth factor (IGF) system plays a key role in the development and progression of several types of cancer. Insulin/IGF signaling, in cooperation with chronic low-grade inflammation, is also an...

Fitness Trade-Offs Associated with the Evolution of Resistance to Antifungal Drug Combinations.

Cell reports

Hill JA, O'Meara TR, Cowen LE.
PMID: 25660029
Cell Rep. 2015 Feb 10;10(5):809-819. doi: 10.1016/j.celrep.2015.01.009. Epub 2015 Feb 05.

The evolution of drug resistance threatens human health worldwide. An emerging strategy to mitigate drug resistance is combination therapy. The fate of multidrug-resistant pathogens depends on their fitness relative to susceptible counterparts, yet the fitness consequences of multidrug resistance...

Showing 1 to 12 of 1001 entries