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Showing 1 to 12 of 200 entries
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Evolution of the FGF Gene Family.

International journal of evolutionary biology

Oulion S, Bertrand S, Escriva H.
PMID: 22919541
Int J Evol Biol. 2012;2012:298147. doi: 10.1155/2012/298147. Epub 2012 Aug 07.

Fibroblast Growth Factors (FGFs) are small proteins generally secreted, acting through binding to transmembrane tyrosine kinase receptors (FGFRs). Activation of FGFRs triggers several cytoplasmic cascades leading to the modification of cell behavior. FGFs play critical roles in a variety...

The Efficacy of Fibroblast Growth Factor for the Treatment of Chronic Vocal Fold Scarring: From Animal Model to Clinical Application.

Clinical and experimental otorhinolaryngology

Ban MJ, Park JH, Kim JW, Park KN, Lee JY, Kim HK, Lee SW.
PMID: 27671715
Clin Exp Otorhinolaryngol. 2017 Dec;10(4):349-356. doi: 10.21053/ceo.2016.00941. Epub 2016 Sep 27.

OBJECTIVES: This study assessed the regenerative efficacy of basic fibroblast growth factor (FGF) in a rabbit model of chronic vocal fold scarring and then confirmed its utility and safety in a prospective trial of patients with this condition.METHODS: FGF...

Phosphaturic mesenchymal tumor (PMT): exceptionally rare disease, yet crucial not to miss.

Autopsy & case reports

Ghorbani-Aghbolaghi A, Darrow MA, Wang T.
PMID: 29043208
Autops Case Rep. 2017 Sep 30;7(3):32-37. doi: 10.4322/acr.2017.031. eCollection 2017.

Phosphaturic mesenchymal tumors (PMTs) are very rare tumors which are frequently associated with Tumor Induced Osteomalacia (TIO), a paraneoplastic syndrome that manifests as renal phosphate wasting. The tumor cells produce a peptide hormone-like substance known as fibroblast growth factor...

Fibroblast growth factors as tissue repair and regeneration therapeutics.

PeerJ

Nunes QM, Li Y, Sun C, Kinnunen TK, Fernig DG.
PMID: 26793421
PeerJ. 2016 Jan 12;4:e1535. doi: 10.7717/peerj.1535. eCollection 2016.

Cell communication is central to the integration of cell function required for the development and homeostasis of multicellular animals. Proteins are an important currency of cell communication, acting locally (auto-, juxta-, or paracrine) or systemically (endocrine). The fibroblast growth...

Localisation of acidic and basic fibroblast growth factors during mouse palate development and their effects on mouse palate mesenchyme cells in vitro.

Roux's archives of developmental biology : the official organ of the EDBO

Sharpe PM, Brunet CL, Foreman DM, Ferguson MW.
PMID: 28305990
Rouxs Arch Dev Biol. 1993 Feb;202(3):132-143. doi: 10.1007/BF00365303.

The distribution of acidic and basic fibroblast growth factors (aFGF, bFGF) was mapped during mouse embryonic palate development. Generally, they localised most intensely in the basement membrane and epithelia rather than the mesenchyme. Localisation was predominantly restricted to the...

Molecular pathways of pannexin1-mediated neurotoxicity.

Frontiers in physiology

Shestopalov VI, Slepak VZ.
PMID: 24575045
Front Physiol. 2014 Feb 11;5:23. doi: 10.3389/fphys.2014.00023. eCollection 2014.

Pannexin1 (Panx1) forms non-selective membrane channels, structurally similar to gap junction hemichannels, and are permeable to ions, nucleotides, and other small molecules below 900 Da. Panx1 activity has been implicated in paracrine signaling and inflammasome regulation. Recent studies in...

Craniosynostosis.

Indian journal of plastic surgery : official publication of the Association of Plastic Surgeons of India

Sharma RK.
PMID: 23960302
Indian J Plast Surg. 2013 Jan;46(1):18-27. doi: 10.4103/0970-0358.113702.

Craniosynostosis is a premature pathologic fusion of one or more cranial vault sutures that leads to abnormal shape of the skull. The fused sutures lead to restricted growth in some areas and compensatory bossing in other areas. The head...

Normal and malignant human colonic mucosa contain acidic and basic fibroblast growth-factors.

International journal of oncology

Wilkinson M, Gardner M, Gould P, Taylor B, Fernig D.
PMID: 21573455
Int J Oncol. 1993 Nov;3(5):933-6. doi: 10.3892/ijo.3.5.933.

Quantification of the amount of heparin-binding growth factor activity present in homogenates of normal and malignant human colon mucosa in terms of basic fibroblast growth factor (bFGF) indicates that 6-29 ng/g tissue of bFGF-like activity was present in five...

Expression patterns of acidic and basic fibroblast growth factor in loach fish embryos.

Fish physiology and biochemistry

Inaba K, Seno M, Morino H.
PMID: 24194252
Fish Physiol Biochem. 1996 Aug;15(4):333-8. doi: 10.1007/BF02112360.

Heparin-binding fractions were taken from the heparin sepharose columns on which extracts of loach fish (Misgurnus anguillicaudatus) embryos from blastula, gastrula, 4-8 and 12-16 somites stages were applied. These heparin-binding fractions, except the fraction derived from 12-16 somite embryos,...

Does single intramuscular application of autologous conditioned plasma influence systemic circulating growth factors?.

Journal of sports science & medicine

Schippinger G, Fankhauser F, Oettl K, Spirk S, Hofmann P.
PMID: 24149367
J Sports Sci Med. 2012 Sep 01;11(3):551-6. eCollection 2012.

Platelet-rich plasma (PRP) has been employed to treat sports injuries to possibly accelerate healing and regeneration. This method offers some potential, especially for athletes. Growth factors are generally prohibited by the World Anti Doping Agency with exception to PRP...

Ridge preservation using basic fibroblast growth factor-2 and collagenated biphasic calcium phosphate in beagle dogs.

Journal of periodontal & implant science

Sohn B, Hwang M, Kim S, Kim HI, Ku Y.
PMID: 29333324
J Periodontal Implant Sci. 2017 Dec;47(6):381-387. doi: 10.5051/jpis.2017.47.6.381. Epub 2017 Dec 31.

PURPOSE: The aim of this study was to evaluate volumetric and histologic changes in edentulous alveolar ridge areas after ridge preservation using basic fibroblast growth factor-2 (bFGF-2) in combination with collagenated biphasic calcium phosphate (BCP).METHODS: The experiments were performed...

Fibroblast growth factor receptor signaling plays a key role in transformation induced by the TMPRSS2/ERG fusion gene and decreased PTEN.

Oncotarget

Shao L, Wang J, Karatas OF, Feng S, Zhang Y, Creighton CJ, Ittmann M.
PMID: 29581856
Oncotarget. 2018 Feb 12;9(18):14456-14471. doi: 10.18632/oncotarget.24470. eCollection 2018 Mar 06.

Prostate cancer is the most common visceral malignancy and the second leading cause of cancer deaths in US men. Correlative studies in human prostate cancers reveal a frequent association of the TMPRSS2/ERG (TE) fusion gene with loss of PTEN...

Showing 1 to 12 of 200 entries