Björn C, Håkansson J, Myhrman E, Sjöstrand V, Haug T, Lindgren K, Blencke HM, Stensvåg K, Mahlapuu M.
AMB Express. 2012 Dec 13;2(1):67. doi: 10.1186/2191-0855-2-67.
Bacterial resistance against antibiotic treatment has become a major threat to public health. Antimicrobial peptides (AMPs) have emerged as promising alternative agents for treatment of infectious diseases. This study characterizes novel synthetic peptides sequentially derived from the AMP centrocin...
Frontiers in pharmacology
Gibbs PE, Tudor C, Maines MD.
Front Pharmacol. 2012 Mar 13;3:31. doi: 10.3389/fphar.2012.00031. eCollection 2012.
The expanse of human biliverdin reductase (hBVR) functions in the cells is arguably unmatched by any single protein. hBVR is a Ser/Thr/Tyr-kinase, a scaffold protein, a transcription factor, and an intracellular transporter of gene regulators. hBVR is an upstream...
Drug development research
Volpina OM, Koroev DO, Serebryakova MV, Volkova TD, Kamynina AV, Bobkova NV.
Drug Dev Res. 2021 Dec;82(8):1217-1226. doi: 10.1002/ddr.21836. Epub 2021 May 31.
The receptor for advanced glycation end products (RAGE) plays an essential role in Alzheimer's disease (AD). We previously demonstrated that a fragment (60-76) of RAGE improved the memory of olfactory bulbectomized (OBX) and Tg 5 × FAD mice -...
Frontiers in immunology
Mariotton J, Sams A, Cohen E, Sennepin A, Siracusano G, Sanvito F, Edvinsson L, Delongchamps NB, Zerbib M, Lopalco L, Bomsel M, Ganor Y.
Front Immunol. 2021 Dec 08;12:785072. doi: 10.3389/fimmu.2021.785072. eCollection 2021.
BACKGROUND: The vasodilator neuropeptide calcitonin gene-related peptide (CGRP) plays both detrimental and protective roles in different pathologies. CGRP is also an essential component of the neuro-immune dialogue between nociceptors and mucosal immune cells. We previously discovered that CGRP is...
Biotechnology and bioengineering
Capellas M, Caminal G, Gonzalez G, López-Santín J, Clapés P.
Biotechnol Bioeng. 1997 Nov 20;56(4):456-63. doi: 10.1002/(SICI)1097-0290(19971120)56:4<456::AID-BIT11>3.0.CO;2-A.
The kinetically controlled condensation reaction of Z-Gly-Trp-Met-OR(1) (R(1): Et, Al, Cam) and H-Asp-(OR(2))-Phe-NH(2) (R(2): H, Bu(t)) catalyzed by alpha-chymotrypsin deposited onto polyamide in organic media was studied. The effect of the drying process of the enzyme-support preparation, substrate concentrations,...
Nonlinearity in biology, toxicology, medicine
Pentreath VW, Mead C.
Nonlinearity Biol Toxicol Med. 2004 Jan;2(1):45-63. doi: 10.1080/15401420490426990.
The effect of amyloid beta-peptide (betaAP), which can have both neurotrophic or neurotoxic effects on neurons and has been implicated in the pathogenesis of Alzheimer's disease (AD), was studied on astrocytes using primary cultures and astrocyte cell lines (rat...
Jones AM, Quail PH.
Planta. 1989 May;178(2):147-56. doi: 10.1007/BF00393189.
We have undertaken a study of the structure of the amino-terminal domain of the phytochrome polypeptide purified from Avena sativa L. Amino-acid sequencing was used to indentify arginine 52 as the precise location of a conformation-specific cleavage of phytochrome...
Kumar N, Sood D, Tomar R, Chandra R.
ACS Omega. 2019 Dec 03;4(25):21370-21380. doi: 10.1021/acsomega.9b03035. eCollection 2019 Dec 17.
The mankind relies on the use of antibiotics for a healthy life. The epidemic-like emergence of drug-resistant bacterial strains is increasingly becoming one of the leading causes of morbidity and mortality, which gives rise to design a potential antimicrobial...
Deyl Z, Rosmus J, Adam M.
FEBS Lett. 1971 Jan 12;12(3):176-178. doi: 10.1016/0014-5793(71)80062-5.
No abstract available.
Current opinion in chemical biology
Samdin TD, Kreutzer AG, Nowick JS.
Curr Opin Chem Biol. 2021 Oct;64:106-115. doi: 10.1016/j.cbpa.2021.05.004. Epub 2021 Jul 03.
The assembly of amyloidogenic peptides and proteins, such as the β-amyloid peptide, α-synuclein, huntingtin, tau, and islet amyloid polypeptide, into amyloid fibrils and oligomers is directly linked to amyloid diseases, such as Alzheimer's, Parkinson's, and Huntington's diseases, frontotemporal dementias,...
Plants (Basel, Switzerland)
Rogozhin EA, Vasilchenko AS, Barashkova AS, Smirnov AN, Zavriev SK, Demushkin VP.
Plants (Basel). 2020 Sep 30;9(10). doi: 10.3390/plants9101294.
We report the inhibitory effect of peptide extracts obtained from seven medicinal plants against a causative agent of late blight disease
Frontiers in pharmacology
Kryukova EV, Egorova NS, Kudryavtsev DS, Lebedev DS, Spirova EN, Zhmak MN, Garifulina AI, Kasheverov IE, Utkin YN, Tsetlin VI.
Front Pharmacol. 2019 Jul 03;10:748. doi: 10.3389/fphar.2019.00748. eCollection 2019.
The proteins of the Ly6 family have a three-finger folding as snake venom α-neurotoxins, targeting nicotinic acetylcholine receptors (nAChRs), and some of them, like mammalian secreted Ly6/uPAR protein (SLURP1) and membrane-attached Ly-6/neurotoxin (Lynx1), also interact with distinct nAChR subtypes....