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Showing 1 to 12 of 129 entries
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Q&A: Mina Bissell on tumors as organs.

Cancer discovery

Bissell M.
PMID: 23319753
Cancer Discov. 2013 Jan;3(1):7. doi: 10.1158/2159-8290.CD-ND2012-044.

No abstract available.

The role played by the microenvironment in site-specific metastasis.

Cancer letters

Klein-Goldberg A, Maman S, Witz IP.
PMID: 23988268
Cancer Lett. 2014 Sep 28;352(1):54-8. doi: 10.1016/j.canlet.2013.08.029. Epub 2013 Aug 27.

Cancer cells that disseminate to metastatic sites may progress to frank metastasis or persist as dormant micrometastasis. Significant progress has been made in defining the genetic and phenotypic cancer-cell-autonomous determinants of metastasis and in the understanding of the cross-talk...

Continuity of transcriptomes among colorectal cancer subtypes based on meta-analysis.

Genome biology

Ma S, Ogino S, Parsana P, Nishihara R, Qian Z, Shen J, Mima K, Masugi Y, Cao Y, Nowak JA, Shima K, Hoshida Y, Giovannucci EL, Gala MK, Chan AT, Fuchs CS, Parmigiani G, Huttenhower C, Waldron L.
PMID: 30253799
Genome Biol. 2018 Sep 25;19(1):142. doi: 10.1186/s13059-018-1511-4.

BACKGROUND: Previous approaches to defining subtypes of colorectal carcinoma (CRC) and other cancers based on transcriptomes have assumed the existence of discrete subtypes. We analyze gene expression patterns of colorectal tumors from a large number of patients to test...

Metabolic Remodeling as a Way of Adapting to Tumor Microenvironment (TME), a Job of Several Holders.

Advances in experimental medicine and biology

Serpa J.
PMID: 32130691
Adv Exp Med Biol. 2020;1219:1-34. doi: 10.1007/978-3-030-34025-4_1.

The microenvironment depends and generates dependence on all the cells and structures that share the same niche, the biotope. The contemporaneous view of the tumor microenvironment (TME) agrees with this idea. The cells that make up the tumor, whether...

Wnt Signaling: Paths for Cancer Progression.

Advances in experimental medicine and biology

Carreira-Barbosa F, Nunes SC.
PMID: 32130700
Adv Exp Med Biol. 2020;1219:189-202. doi: 10.1007/978-3-030-34025-4_10.

The Wnt signaling pathways are well known for having several pivotal roles during embryonic development. However, the same developmental signaling pathways also present key roles in cancer initiation and progression. In this chapter, several issues regarding the roles of...

Cancer Evolution Constrained by the Immune Microenvironment.

Cell

McGranahan N, Swanton C.
PMID: 28841415
Cell. 2017 Aug 24;170(5):825-827. doi: 10.1016/j.cell.2017.08.012.

Tumor development is a Darwinian evolutionary process, involving the interplay between cancer subclones and the local immune microenvironment. These complex interactions are highlighted in this issue of Cell by the results from Jiménez-Sánchez et al. of a deep analysis...

Ketogenic diet in the treatment of cancer - Where do we stand?.

Molecular metabolism

Weber DD, Aminzadeh-Gohari S, Tulipan J, Catalano L, Feichtinger RG, Kofler B.
PMID: 31399389
Mol Metab. 2020 Mar;33:102-121. doi: 10.1016/j.molmet.2019.06.026. Epub 2019 Jul 27.

BACKGROUND: Cancer is one of the greatest public health challenges worldwide, and we still lack complementary approaches to significantly enhance the efficacy of standard anticancer therapies. The ketogenic diet, a high-fat, low-carbohydrate diet with adequate amounts of protein, appears...

Integrating genetic and non-genetic determinants of cancer evolution by single-cell multi-omics.

Nature reviews. Genetics

Nam AS, Chaligne R, Landau DA.
PMID: 32807900
Nat Rev Genet. 2021 Jan;22(1):3-18. doi: 10.1038/s41576-020-0265-5. Epub 2020 Aug 17.

Cancer represents an evolutionary process through which growing malignant populations genetically diversify, leading to tumour progression, relapse and resistance to therapy. In addition to genetic diversity, the cell-to-cell variation that fuels evolutionary selection also manifests in cellular states, epigenetic...

The origin of cancer.

Journal of internal medicine

Toftgård R.
PMID: 33769632
J Intern Med. 2021 May;289(5):601-603. doi: 10.1111/joim.13280. Epub 2021 Mar 26.

No abstract available.

A TME-activated in situ nanogenerator for magnetic resonance/fluorescence/photoacoustic imaging.

Methods in enzymology

Xu S, Shi X, Chu C, Liu G.
PMID: 34353485
Methods Enzymol. 2021;657:145-156. doi: 10.1016/bs.mie.2021.06.029. Epub 2021 Jul 13.

With the rapid development of biomedical imaging, non-invasive imaging method particularly has been widely used in clinical diagnosis. Different imaging methods have their own advantages, such as higher resolution of optical imaging, deeper penetration of acoustic imaging, high resolution...

Clinical Implications of Exosomes: Targeted Drug Delivery for Cancer Treatment.

International journal of molecular sciences

Massey AE, Malik S, Sikander M, Doxtater KA, Tripathi MK, Khan S, Yallapu MM, Jaggi M, Chauhan SC, Hafeez BB.
PMID: 34067896
Int J Mol Sci. 2021 May 17;22(10). doi: 10.3390/ijms22105278.

Exosomes are nanoscale vesicles generated by cells for intercellular communication. Due to their composition, significant research has been conducted to transform these particles into specific delivery systems for various disease states. In this review, we discuss the common isolation...

Microbe-based management for colorectal cancer.

Chinese medical journal

Gao ZY, Cui Z, Yan YQ, Ning LJ, Wang ZH, Hong J.
PMID: 34855639
Chin Med J (Engl). 2021 Dec 01;134(24):2922-2930. doi: 10.1097/CM9.0000000000001887.

ABSTRACT: Colorectal cancer (CRC) is one of the most prevalent, most lethal cancers in the world. Increasing evidence suggests that the intestinal microbiota is closely related to the pathogenesis and prognosis of CRC. The normal microbiota plays an essential...

Showing 1 to 12 of 129 entries