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Yang Y, Du K, Liu Z, et al. Endothelial nitric oxide synthase (eNOS) 4b/a gene polymorphisms and coronary artery disease: evidence from a meta-analysis. Int J Mol Sci. 2014;15(5):7987-8003doi: 10.3390/ijms15057987.
Yang, Y., Du, K., Liu, Z., & Lu, X. (2014). Endothelial nitric oxide synthase (eNOS) 4b/a gene polymorphisms and coronary artery disease: evidence from a meta-analysis. International journal of molecular sciences, 15(5), 7987-8003. https://doi.org/10.3390/ijms15057987
Yang, Yujiao, et al. "Endothelial nitric oxide synthase (eNOS) 4b/a gene polymorphisms and coronary artery disease: evidence from a meta-analysis." International journal of molecular sciences vol. 15,5 (2014): 7987-8003. doi: https://doi.org/10.3390/ijms15057987
Yang Y, Du K, Liu Z, Lu X. Endothelial nitric oxide synthase (eNOS) 4b/a gene polymorphisms and coronary artery disease: evidence from a meta-analysis. Int J Mol Sci. 2014 May 07;15(5):7987-8003. doi: 10.3390/ijms15057987. PMID: 24810690; PMCID: PMC4057714.
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Int J Mol Sci. 2014 May 07;15(5):7987-8003. doi: 10.3390/ijms15057987.

Endothelial nitric oxide synthase (eNOS) 4b/a gene polymorphisms and coronary artery disease: evidence from a meta-analysis.

International journal of molecular sciences

Yujiao Yang, Kang Du, Zhengxia Liu, Xiang Lu

Affiliations

  1. Department of Geriatrics, the Second Affiliated Hospital, Nanjing Medical University, Nanjing 210029, Jiangsu, China. [email protected].
  2. Department of Geriatrics, the Second Affiliated Hospital, Nanjing Medical University, Nanjing 210029, Jiangsu, China. [email protected].
  3. Department of Geriatrics, the Second Affiliated Hospital, Nanjing Medical University, Nanjing 210029, Jiangsu, China. [email protected].
  4. Department of Geriatrics, the Second Affiliated Hospital, Nanjing Medical University, Nanjing 210029, Jiangsu, China. [email protected].

PMID: 24810690 PMCID: PMC4057714 DOI: 10.3390/ijms15057987

Abstract

A variety of studies have suggested that the 4b/a polymorphism in the endothelial nitric oxide synthase (eNOS) was associated with coronary artery disease (CAD) risk. However, the data remain conflicting. The aim of the present meta-analysis was to estimate the overall association between risk of CAD and eNOS 4b/a polymorphism. Case-control, cohort or cross-sectional studies evaluating the association between eNOS 4b/a polymorphism and CAD susceptibility were systematically identified in PubMed up to 31 October 2013. Pooled odds ratios (OR) and corresponding 95% confidence intervals (CIs) were calculated to assess the association in overall and subgroup analyses. A total of 10,617 cases and 8302 controls from 37 studies were included in the study. The results of overall analysis revealed significant positive associations between CAD risk and eNOS 4b/a polymorphism in homozygote comparisons (OR = 1.47, 95% CI = 1.16-1.87), heterozygote comparisons (OR = 1.14, 95% CI = 1.02-1.27) and dominant models (OR = 1.18, 95% CI = 1.06-1.33). In subgroup analyses, similar associations were identified in African individuals, as determined using population-based source subgroups and noted in small-and-moderate sample size subgroups (case sample size or control sample size <500). The current meta-analysis revealed that eNOS 4b/a polymorphisms could be a risk factor for developing CAD, particularly in African populations and population-based subgroups.

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