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Ng SWK, Rouhani FJ, Brunner SF, et al. Convergent somatic mutations in metabolism genes in chronic liver disease. Nature. 2021;598(7881):473-478doi: 10.1038/s41586-021-03974-6.
Ng, S. W. K., Rouhani, F. J., Brunner, S. F., Brzozowska, N., Aitken, S. J., Yang, M., Abascal, F., Moore, L., Nikitopoulou, E., Chappell, L., Leongamornlert, D., Ivovic, A., Robinson, P., Butler, T., Sanders, M. A., Williams, N., Coorens, T. H. H., Teague, J., Raine, K., Butler, A. P., Hooks, Y., Wilson, B., Birtchnell, N., Naylor, H., Davies, S. E., Stratton, M. R., Martincorena, I., Rahbari, R., Frezza, C., Hoare, M., & Campbell, P. J. (2021). Convergent somatic mutations in metabolism genes in chronic liver disease. Nature, 598(7881), 473-478. https://doi.org/10.1038/s41586-021-03974-6
Ng, Stanley W K, et al. "Convergent somatic mutations in metabolism genes in chronic liver disease." Nature vol. 598,7881 (2021): 473-478. doi: https://doi.org/10.1038/s41586-021-03974-6
Ng SWK, Rouhani FJ, Brunner SF, Brzozowska N, Aitken SJ, Yang M, Abascal F, Moore L, Nikitopoulou E, Chappell L, Leongamornlert D, Ivovic A, Robinson P, Butler T, Sanders MA, Williams N, Coorens THH, Teague J, Raine K, Butler AP, Hooks Y, Wilson B, Birtchnell N, Naylor H, Davies SE, Stratton MR, Martincorena I, Rahbari R, Frezza C, Hoare M, Campbell PJ. Convergent somatic mutations in metabolism genes in chronic liver disease. Nature. 2021 Oct;598(7881):473-478. doi: 10.1038/s41586-021-03974-6. Epub 2021 Oct 13. PMID: 34646017.
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Nature. 2021 Oct;598(7881):473-478. doi: 10.1038/s41586-021-03974-6. Epub 2021 Oct 13.

Convergent somatic mutations in metabolism genes in chronic liver disease.

Nature

Stanley W K Ng, Foad J Rouhani, Simon F Brunner, Natalia Brzozowska, Sarah J Aitken, Ming Yang, Federico Abascal, Luiza Moore, Efterpi Nikitopoulou, Lia Chappell, Daniel Leongamornlert, Aleksandra Ivovic, Philip Robinson, Timothy Butler, Mathijs A Sanders, Nicholas Williams, Tim H H Coorens, Jon Teague, Keiran Raine, Adam P Butler, Yvette Hooks, Beverley Wilson, Natalie Birtchnell, Huw Naylor, Susan E Davies, Michael R Stratton, Iñigo Martincorena, Raheleh Rahbari, Christian Frezza, Matthew Hoare, Peter J Campbell

Affiliations

  1. Cancer Genome Project, Wellcome Sanger Institute, Hinxton, UK.
  2. Department of Surgery, Addenbrooke's Hospital, Cambridge, UK.
  3. CRUK Cambridge Institute, Cambridge, UK.
  4. Department of Pathology, Addenbrooke's Hospital, Cambridge, UK.
  5. MRC Toxicology Unit, University of Cambridge, Cambridge, UK.
  6. MRC Cancer Unit, University of Cambridge, Cambridge, UK.
  7. Department of Hematology, Erasmus University Medical Center, Rotterdam, The Netherlands.
  8. CRUK Cambridge Institute, Cambridge, UK. [email protected].
  9. Department of Medicine, University of Cambridge, Addenbrooke's Hospital, Cambridge, UK. [email protected].
  10. Cancer Genome Project, Wellcome Sanger Institute, Hinxton, UK. [email protected].
  11. Stem Cell Institute, University of Cambridge, Cambridge, UK. [email protected].

PMID: 34646017 DOI: 10.1038/s41586-021-03974-6

Abstract

The progression of chronic liver disease to hepatocellular carcinoma is caused by the acquisition of somatic mutations that affect 20-30 cancer genes

© 2021. The Author(s), under exclusive licence to Springer Nature Limited.

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