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Showing 1 to 12 of 845 entries
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Hesperidin Suppresses Melanosome Transport by Blocking the Interaction of Rab27A-Melanophilin.

Biomolecules & therapeutics

Kim B, Lee JY, Lee HY, Nam KY, Park J, Lee SM, Kim JE, Lee JD, Hwang JS.
PMID: 24244821
Biomol Ther (Seoul). 2013 Sep 30;21(5):343-8. doi: 10.4062/biomolther.2013.032.

We investigated the inhibitory effects of hesperidin on melanogenesis. To find melanosome transport inhibitor from natural products, we collected the structural information of natural products from Korea Food and Drug Administration (KFDA) and performed pharmacophore-based in silico screening for...

Oxidative stress affects retinal pigment epithelial cell survival through epidermal growth factor receptor/AKT signaling pathway.

International journal of ophthalmology

Chen XD, Su MY, Chen TT, Hong HY, Han AD, Li WS.
PMID: 28503420
Int J Ophthalmol. 2017 Apr 18;10(4):507-514. doi: 10.18240/ijo.2017.04.02. eCollection 2017.

AIM: To investigate the cross-talk between oxidative stress and the epidermal growth factor receptor (EGFR)/AKT signaling pathway in retinal pigment epithelial (RPE) cells.METHODS: Human RPE cell lines (ARPE-19 cell) were treated with different doses of epidermal growth factor (EGF)...

Resistive index as a predictor of renal progression in patients with moderate renal dysfunction regardless of angiotensin converting enzyme inhibitor or angiotensin receptor antagonist medication.

Kidney research and clinical practice

Kim JH, Lee SM, Son YK, Kim SE, An WS.
PMID: 28392998
Kidney Res Clin Pract. 2017 Mar;36(1):58-67. doi: 10.23876/j.krcp.2017.36.1.58. Epub 2017 Mar 31.

BACKGROUND: Previous studies have shown that a higher resistive index (RI) on renal duplex ultrasonography was related with renal progression and acute kidney injury, especially in patients with chronic kidney disease (CKD) using an angiotensin converting enzyme inhibitor (ACEI)...

Effect of Omega-3 Fatty Acid on the Fatty Acid Content of the Erythrocyte Membrane and Proteinuria in Patients with Diabetic Nephropathy.

International journal of endocrinology

Lee SM, Chung SH, Park Y, Park MK, Son YK, Kim SE, An WS.
PMID: 26089878
Int J Endocrinol. 2015;2015:208121. doi: 10.1155/2015/208121. Epub 2015 May 18.

Diabetic nephropathy is the leading cause of end-stage renal disease and is associated with an increased risk of cardiovascular events. Dietary omega-3 fatty acid (FA) has cardioprotective effect and is associated with a slower deterioration of albumin excretion in...

Repeated Glucose Deprivation/Reperfusion Induced PC-12 Cell Death through the Involvement of FOXO Transcription Factor.

Diabetes & metabolism journal

Han N, Kim YJ, Park SM, Kim SM, Lee JS, Jung HS, Lee EJ, Kim TK, Kim TN, Kwon MJ, Lee SH, Kim MK, Rhee BD, Park JH.
PMID: 27766247
Diabetes Metab J. 2016 Oct;40(5):396-405. doi: 10.4093/dmj.2016.40.5.396. Epub 2016 Sep 01.

BACKGROUND: Cognitive impairment and brain damage in diabetes is suggested to be associated with hypoglycemia. The mechanisms of hypoglycemia-induced neural death and apoptosis are not clear and reperfusion injury may be involved. Recent studies show that glucose deprivation/reperfusion induced...

Maternal and neonatal outcomes in multiple pregnancy: A multicentre study in the Beijing population.

Chronic diseases and translational medicine

Su RN, Zhu WW, Wei YM, Wang C, Feng H, Lin L, Yang HX.
PMID: 29063007
Chronic Dis Transl Med. 2015 Sep 26;1(4):197-202. doi: 10.1016/j.cdtm.2015.08.004. eCollection 2015 Dec.

OBJECTIVE: To compare the adverse maternal and neonatal outcomes of multiple pregnancy and singleton pregnancy from multiple medical centers in Beijing.METHODS: Data concerning maternal and neonatal adverse outcomes in multiple and singleton pregnancies were collected from 15 hospitals in...

Development of the transcallosal motor fiber from the corticospinal tract in the human brain: diffusion tensor imaging study.

Frontiers in human neuroscience

Kwon HG, Son SM, Jang SH.
PMID: 24672465
Front Hum Neurosci. 2014 Mar 18;8:153. doi: 10.3389/fnhum.2014.00153. eCollection 2014.

Transcallosal motor fiber (TCMF) plays a role in interhemispheric inhibition (IHI) between two primary motor cortices. IHI has been an important concept in development of the motor system of the brain. Many studies have focused on the research of...

Luteolin Ameliorates Hypertensive Vascular Remodeling through Inhibiting the Proliferation and Migration of Vascular Smooth Muscle Cells.

Evidence-based complementary and alternative medicine : eCAM

Su J, Xu HT, Yu JJ, Gao JL, Lei J, Yin QS, Li B, Pang MX, Su MX, Mi WJ, Chen SH, Lv GY.
PMID: 26495010
Evid Based Complement Alternat Med. 2015;2015:364876. doi: 10.1155/2015/364876. Epub 2015 Sep 30.

Objectives. Preliminary researches showed that luteolin was used to treat hypertension. However, it is still unclear whether luteolin has effect on the hypertensive complication such as vascular remodeling. The present study was designed to investigate the effect of luteolin...

Anti-inflammatory effects of Cryptotympana atrata Fabricius slough shed on contact dermatitis induced by dinitrofluorobenzene in mice.

Pharmacognosy magazine

Kim M, Kim H, Ryu J, Jo S, Lee G, Ryu MH, Kim H, Cho SI.
PMID: 24991117
Pharmacogn Mag. 2014 Apr;10:S377-82. doi: 10.4103/0973-1296.133288.

BACKGROUND: The slough shed of Cryptotympana atrata Fabricius is widely used to treat skin diseases in China, Japan, and Korea.OBJECTIVE: To investigate the anti-inflammatory effects of C. atrata on contact dermatitis.MATERIALS AND METHODS: We investigated the effects of C....

Effect of triclosan-coated sutures on surgical site infection after gastric cancer surgery via midline laparotomy.

Annals of surgical treatment and research

Jung KH, Oh SJ, Choi KK, Kim SM, Choi MG, Lee JH, Noh JH, Sohn TS, Bae JM, Kim S.
PMID: 25485239
Ann Surg Treat Res. 2014 Dec;87(6):311-8. doi: 10.4174/astr.2014.87.6.311. Epub 2014 Nov 28.

PURPOSE: Surgical site infection (SSI) after open abdominal surgery is still a frequently reported nosocomial infection. To reduce the incidence of SSI, triclosan-coated sutures with antiseptic activity (Vicryl Plus) were developed. The aim of this study was to analyze...

Dynamic Changes of Treg and Th17 Cells and Related Cytokines Closely Correlate With the Virological and Biochemical Response in Chronic Hepatitis B Patients Undergoing Nucleos(t)ide Analogues Treatment.

Hepatitis monthly

Yu XP, Guo RY, Su ML, Ming DS, Lin CZ, Deng Y, Lin ZZ, Su ZJ.
PMID: 24403916
Hepat Mon. 2013 Dec 23;13(12):e15332. doi: 10.5812/hepatmon.15332. eCollection 2013.

BACKGROUND: The restoration of HBV-specific T-cell response during antiviral therapy is associated with CD4+T-cell activity. Treg cells and Th17 cells are subtypes of CD4+T cell. However, it has remained unknown how the Treg and Th17 cells and their associated...

Background Parenchymal Enhancement of the Contralateral Normal Breast: Association with Tumor Response in Breast Cancer Patients Receiving Neoadjuvant Chemotherapy.

Translational oncology

Chen JH, Yu HJ, Hsu C, Mehta RS, Carpenter PM, Su MY.
PMID: 26055178
Transl Oncol. 2015 Jun;8(3):204-9. doi: 10.1016/j.tranon.2015.04.001.

PURPOSE: This study investigated the association between background parenchymal enhancement (BPE) and pathologic response to neoadjuvant chemotherapy (NAC).METHODS: A total of 46 patients diagnosed with invasive breast cancer were analyzed. Each patient had three magnetic resonance imaging (MRI) studies,...

Showing 1 to 12 of 845 entries