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Showing 1 to 12 of 1574 entries
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Guanylyl cyclase/natriuretic peptide receptor-A signaling antagonizes phosphoinositide hydrolysis, Ca(2+) release, and activation of protein kinase C.

Frontiers in molecular neuroscience

Pandey KN.
PMID: 25202235
Front Mol Neurosci. 2014 Aug 22;7:75. doi: 10.3389/fnmol.2014.00075. eCollection 2014.

Thus far, three related natriuretic peptides (NPs) and three distinct sub-types of cognate NP receptors have been identified and characterized based on the specific ligand binding affinities, guanylyl cyclase activity, and generation of intracellular cGMP. Atrial and brain natriuretic...

Novel Therapies for Diabetic Kidney Disease: Storied Past and Forward Paths.

Diabetes spectrum : a publication of the American Diabetes Association

Dieter BP, Alicic RZ, Meek RL, Anderberg RJ, Cooney SK, Tuttle KR.
PMID: 26300609
Diabetes Spectr. 2015 Aug;28(3):167-74. doi: 10.2337/diaspect.28.3.167.

IN BRIEF Current therapeutic approaches are only moderately efficacious at preventing the progression of diabetic kidney disease (DKD). As the number of people with DKD continues to rise worldwide, there is an urgent need for novel therapies. A better...

Early Intervention of Didang Decoction on MLCK Signaling Pathways in Vascular Endothelial Cells of Type 2 Diabetic Rats.

International journal of endocrinology

Ye S, Song Z, Li J, Li C, Yang J, Chang B.
PMID: 27703477
Int J Endocrinol. 2016;2016:6704851. doi: 10.1155/2016/6704851. Epub 2016 Sep 15.

In the study, type 2 diabetic rat model was established using streptozotocin (STZ) combined with a high-fat diet, and the rats were divided into control and diabetic groups. Diabetic groups were further divided into nonintervening, simvastatin, Didang Decoction (DDD)...

Synaptic Activity and Muscle Contraction Increases PDK1 and PKCβI Phosphorylation in the Presynaptic Membrane of the Neuromuscular Junction.

Frontiers in molecular neuroscience

Hurtado E, Cilleros V, Just L, Simó A, Nadal L, Tomàs M, Garcia N, Lanuza MA, Tomàs J.
PMID: 28890686
Front Mol Neurosci. 2017 Aug 25;10:270. doi: 10.3389/fnmol.2017.00270. eCollection 2017.

Conventional protein kinase C βI (cPKCβI) is a conventional protein kinase C (PKC) isoform directly involved in the regulation of neurotransmitter release in the neuromuscular junction (NMJ). It is located exclusively at the nerve terminal and both synaptic activity...

Structure, Function, Pharmacology, and Therapeutic Potential of the G Protein, Gα/q,11.

Frontiers in cardiovascular medicine

Kamato D, Thach L, Bernard R, Chan V, Zheng W, Kaur H, Brimble M, Osman N, Little PJ.
PMID: 26664886
Front Cardiovasc Med. 2015 Mar 24;2:14. doi: 10.3389/fcvm.2015.00014. eCollection 2015.

G protein coupled receptors (GPCRs) are one of the major classes of cell surface receptors and are associated with a group of G proteins consisting of three subunits termed alpha, beta, and gamma. G proteins are classified into four...

Effect of Tamoxifen and Lithium on Treatment of Acute Mania Symptoms in Children and Adolescents.

Iranian journal of child neurology

Fallah E, Arman S, Najafi M, Shayegh B.
PMID: 27247580
Iran J Child Neurol. 2016;10(2):16-25.

OBJECTIVE: Many studies have supported the role of protein kinase C (PKC) inhibitors in the physiopathology and treatment of bipolar disorder in adults. Tamoxifen is one of the drugs with the effect of PKC inhibition. This study aimed to...

2D DIGE Does Not Reveal all: A Scotopic Report Suggests Differential Expression of a Single "Calponin Family Member" Protein for Tetany of Sphincters!.

Frontiers in medicine

Chaudhury A.
PMID: 26151053
Front Med (Lausanne). 2015 Jun 18;2:42. doi: 10.3389/fmed.2015.00042. eCollection 2015.

Using 2D differential gel electrophoresis (DIGE) and mass spectrometry (MS), a recent report by Rattan and Ali (2015) compared proteome expression between tonically contracted sphincteric smooth muscles of the internal anal sphincter (IAS), in comparison to the adjacent rectum...

Cladosporium cladosporioides from the perspectives of medical and biotechnological approaches.

3 Biotech

AlMatar M, Makky EA.
PMID: 28330073
3 Biotech. 2016 Jun;6(1):4. doi: 10.1007/s13205-015-0323-4. Epub 2015 Dec 31.

Fungi are important natural product sources that have enormous potential for the production of novel compounds for use in pharmacology, agricultural applications and industry. Compared with other natural sources such as plants, fungi are highly diverse but understudied. However,...

Hyperglycemic Stress and Carbon Stress in Diabetic Glucotoxicity.

Aging and disease

Luo X, Wu J, Jing S, Yan LJ.
PMID: 26816666
Aging Dis. 2016 Jan 02;7(1):90-110. doi: 10.14336/AD.2015.0702. eCollection 2016 Jan.

Diabetes and its complications are caused by chronic glucotoxicity driven by persistent hyperglycemia. In this article, we review the mechanisms of diabetic glucotoxicity by focusing mainly on hyperglycemic stress and carbon stress. Mechanisms of hyperglycemic stress include reductive stress...

Correction: Expression of Protein Kinase C Isoforms in Pancreatic Islets and Liver of Male Goto-Kakizaki Rats, a Model of Type 2 Diabetes.

PloS one

Seed Ahmed M, Pelletier J, Leumann H, Gu HF, Östenson CG.
PMID: 26485395
PLoS One. 2015 Oct 20;10(10):e0141292. doi: 10.1371/journal.pone.0141292. eCollection 2015.

No abstract available.

Antimanic Treatment With Tamoxifen Affects Brain Chemistry: A Double-Blind, Placebo-Controlled Proton Magnetic Resonance Spectroscopy Study.

Biological psychiatry. Cognitive neuroscience and neuroimaging

Yildiz A, Aydin B, Gökmen N, Yurt A, Cohen B, Keskinoglu P, Öngür D, Renshaw P.
PMID: 27231722
Biol Psychiatry Cogn Neurosci Neuroimaging. 2016 Mar;1(2):125-131. doi: 10.1016/j.bpsc.2015.12.002.

BACKGROUND: The antimanic efficacy of a protein kinase C (PKC) inhibitor, tamoxifen, has been tested in several clinical trials, all reporting positive results. However, mechanisms underlying the observed clinical effects requires further confirmation through studies of biological markers.METHODS: We...

A new Vitreoscilla filiformis extract grown on spa water-enriched medium activates endogenous cutaneous antioxidant and antimicrobial defenses through a potential Toll-like receptor 2/protein kinase C, zeta transduction pathway.

Clinical, cosmetic and investigational dermatology

Mahe YF, Perez MJ, Tacheau C, Fanchon C, Martin R, Rousset F, Seite S.
PMID: 24039440
Clin Cosmet Investig Dermatol. 2013 Aug 30;6:191-6. doi: 10.2147/CCID.S47324. eCollection 2013.

Vitreoscilla filiformis (VF) biomass (VFB) has been widely used in cosmetic preparations and shown to modulate the major inducible free-radical scavenger mitochondrial superoxide dismutase in skin cells. By adding La Roche-Posay (LRP) thermal spring water to the VF culture...

Showing 1 to 12 of 1574 entries