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Showing 1 to 12 of 1871 entries
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Methodology or method? A critical review of qualitative case study reports

case studies

Hyett N, Kenny A, Dickson-Swift V.
GSID: sYI7DqAXtLEJ
N Hyett, A Kenny, V Dickson-Swift - … journal of qualitative studies …, 2014 - Taylor & Francis

… descriptions of published case studies. Three high-impact qualitative methods journals were searched to locate case studies published in … Articles were categorized as health and health services (n=12), social sciences and anthropology (n=7), or methods (n=15) case studies....

Characterization of forebrain neurons derived from late-onset Huntington's disease human embryonic stem cell lines.

Frontiers in cellular neuroscience

Niclis JC, Pinar A, Haynes JM, Alsanie W, Jenny R, Dottori M, Cram DS.
PMID: 23576953
Front Cell Neurosci. 2013 Apr 05;7:37. doi: 10.3389/fncel.2013.00037. eCollection 2013.

Huntington's disease (HD) is an incurable neurodegenerative disorder caused by a CAG repeat expansion in exon 1 of the Huntingtin (HTT) gene. Recently, induced pluripotent stem cell (iPSC) lines carrying atypical and aggressive (CAG60+) HD variants have been generated...

Fertility preservation during cancer treatment: clinical guidelines.

Cancer management and research

Rodriguez-Wallberg KA, Oktay K.
PMID: 24623991
Cancer Manag Res. 2014 Mar 04;6:105-17. doi: 10.2147/CMAR.S32380. eCollection 2014.

The majority of children, adolescents, and young adults diagnosed with cancer today will become long-term survivors. The threat to fertility that cancer treatments pose to young patients cannot be prevented in many cases, and thus research into methods for...

Next generation sequencing reveals skewing of the T and B cell receptor repertoires in patients with wiskott-Aldrich syndrome.

Frontiers in immunology

O'Connell AE, Volpi S, Dobbs K, Fiorini C, Tsitsikov E, de Boer H, Barlan IB, Despotovic JM, Espinosa-Rosales FJ, Hanson IC, Kanariou MG, Martínez-Beckerat R, Mayorga-Sirera A, Mejia-Carvajal C, Radwan N, Weiss AR, Pai SY, Lee YN, Notarangelo LD.
PMID: 25101082
Front Immunol. 2014 Jul 18;5:340. doi: 10.3389/fimmu.2014.00340. eCollection 2014.

The Wiskott-Aldrich syndrome (WAS) is due to mutations of the WAS gene encoding for the cytoskeletal WAS protein, leading to abnormal downstream signaling from the T cell and B cell antigen receptors (TCR and BCR). We hypothesized that the...

Inflammatory Cyclooxygenase Activity and PGE.

Current immunology reviews

Johansson JU, Woodling NS, Shi J, Andreasson KI.
PMID: 28413375
Curr Immunol Rev. 2015 Aug;11(2):125-131. doi: 10.2174/1573395511666150707181414.

The inflammatory response is a fundamental driving force in the pathogenesis of Alzheimer's disease (AD). In the setting of accumulating immunogenic Aß peptide assemblies, microglia, the innate immune cells of the brain, generate a non-resolving immune response and fail...

An UHPLC-MS/MS method for the simultaneous determination of ampicillin and sulbactam in human plasma and urine.

Bioanalysis

Parker SL, Adnan S, Ordóñez Meija JL, Paterson DL, Lipman J, Roberts JA, Wallis SC.
PMID: 26395242
Bioanalysis. 2015 Sep;7(18):2311-2319. doi: 10.4155/bio.15.143. Epub 2015 Sep 23.

BACKGROUND: With few new antibiotics available and an increased prevalence of multidrug-resistant bacteria, optimizing the effectiveness of currently available antibiotics and minimizing the potential for emerging resistance, through PK characterization, is of paramount importance.RESULTS: Inter- and intra-assay results for...

Preoperative imaging markers and PDZ-binding kinase tissue expression predict low-risk disease in endometrial hyperplasias and low grade cancers.

Oncotarget

Berg A, Gulati A, Ytre-Hauge S, Fasmer KE, Mauland KK, Hoivik EA, Husby JA, Tangen IL, Trovik J, Halle MK, Stefansson I, Akslen LA, Woie K, Bjørge L, Salvesen HB, Salvesen ØO, Werner HMJ, Haldorsen IS, Krakstad C.
PMID: 28978135
Oncotarget. 2017 Jul 31;8(40):68530-68541. doi: 10.18632/oncotarget.19708. eCollection 2017 Sep 15.

PURPOSE: Distinguishing complex atypical hyperplasia (CAH) from grade 1 endometrioid endometrial cancer (EECG1) preoperatively may be valuable in order to prevent surgical overtreatment, particularly in patients wishing preserved fertility or in patients carrying increased risk of perioperative complications.MATERIAL AND...

Rapid electrochemical reduction of Ni(II) generates reactive monolayers for conjugated polymer brushes in one step.

Langmuir : the ACS journal of surfaces and colloids

Roy A, Gao J, Bilbrey JA, Huddleston NE, Locklin J.
PMID: 25115133
Langmuir. 2014 Sep 02;30(34):10465-70. doi: 10.1021/la502050n. Epub 2014 Aug 20.

This article reports the development of a robust, one-step electrochemical technique to generate surface-bound conjugated polymers. The electrochemical reduction of arene diazonium salts at the surface of a gold electrode is used to generate tethered bromobenzene monolayers quickly. The...

Targeted Therapies for the Treatment of Pediatric Non-Hodgkin Lymphomas: Present and Future.

Pharmaceuticals (Basel, Switzerland)

Sorge CE, McDaniel JK, Xavier AC.
PMID: 27213405
Pharmaceuticals (Basel). 2016 May 19;9(2). doi: 10.3390/ph9020028.

Pediatric Non-Hodgkin Lymphomas (NHL) are a diverse group of malignancies and as such treatment can vary based on the different biological characteristics of each malignancy. Significant advancements are being made in the treatment and outcomes of this group of...

Theory of Inpatient Circadian Care (TICC): A Proposal for a Middle-Range Theory.

The open nursing journal

Camargo-Sanchez A, Niño CL, Sánchez L, Echeverri S, Gutiérrez DP, Duque AF, Pianeta O, Jaramillo-Gómez JA, Pilonieta MA, Cataño N, Arboleda H, Agostino PV, Alvarez-Baron CP, Vargas R.
PMID: 25767632
Open Nurs J. 2015 Feb 27;9:1-9. doi: 10.2174/1874434601509010001. eCollection 2015.

The circadian system controls the daily rhythms of a variety of physiological processes. Most organisms show physiological, metabolic and behavioral rhythms that are coupled to environmental signals. In humans, the main synchronizer is the light/dark cycle, although non-photic cues...

Decidual Cox2 inhibition improves fetal and maternal outcomes in a preeclampsia-like mouse model.

JCI insight

Sones JL, Cha J, Woods AK, Bartos A, Heyward CY, Lob HE, Isroff CE, Butler SD, Shapiro SE, Dey SK, Davisson RL.
PMID: 27159542
JCI Insight. 2016 Mar 17;1(3). doi: 10.1172/jci.insight.75351.

Preeclampsia (PE) is a disorder of pregnancy that manifests as late gestational maternal hypertension and proteinuria and can be life-threatening to both the mother and baby. It is believed that abnormal placentation is responsible for the cascade of events...

Unique and interactive effects of impulsivity facets on reckless driving and driving under the influence in a high-risk young adult sample.

Personality and individual differences

Luk JW, Trim RS, Karyadi KA, Curry I, Hopfer CJ, Hewitt JK, Stallings MC, Brown SA, Wall TL.
PMID: 29038610
Pers Individ Dif. 2017 Aug 01;114:42-47. doi: 10.1016/j.paid.2017.03.048. Epub 2017 Jan 30.

Risky driving behaviors are disproportionately high among young adults and impulsivity is a robust risk factor. Recent conceptualizations have proposed multidimensional facets of impulsivity comprised of negative urgency, premeditation, perseverance, sensation seeking, and positive urgency (UPPS-P model). Prior studies...

Showing 1 to 12 of 1871 entries