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Comparative study between peripherally and centrally acting sublethal and lethal doses of Leiurus quinquestriatus scorpion venom in rabbits: The usefulness of the sodium channel blocker lidocaine.

Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society

Fatani AJ.
PMID: 23964173
Saudi Pharm J. 2010 Jul;18(3):137-51. doi: 10.1016/j.jsps.2010.05.007. Epub 2010 May 31.

BACKGROUND: Scorpion envenomation is common among desert dwellers, affecting several systems and resulting in multiple organ dysfunction (MOD) or failure (MOF), mainly due to their action on Na(+) channels. Although scorpion venoms toxins do not pass the blood brain...

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Fatani AJ. Comparative study between peripherally and centrally acting sublethal and lethal doses of Leiurus quinquestriatus scorpion venom in rabbits: The usefulness of the sodium channel blocker lidocaine. Saudi Pharm J. 2010;18(3):137-51doi: 10.1016/j.jsps.2010.05.007.
Fatani, A. J. (2010). Comparative study between peripherally and centrally acting sublethal and lethal doses of Leiurus quinquestriatus scorpion venom in rabbits: The usefulness of the sodium channel blocker lidocaine. Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society, 18(3), 137-51. https://doi.org/10.1016/j.jsps.2010.05.007
Fatani, Amal J. "Comparative study between peripherally and centrally acting sublethal and lethal doses of Leiurus quinquestriatus scorpion venom in rabbits: The usefulness of the sodium channel blocker lidocaine." Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society vol. 18,3 (2010): 137-51. doi: https://doi.org/10.1016/j.jsps.2010.05.007
Fatani AJ. Comparative study between peripherally and centrally acting sublethal and lethal doses of Leiurus quinquestriatus scorpion venom in rabbits: The usefulness of the sodium channel blocker lidocaine. Saudi Pharm J. 2010 Jul;18(3):137-51. doi: 10.1016/j.jsps.2010.05.007. Epub 2010 May 31. PMID: 23964173; PMCID: PMC3731021.
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Cytotoxic Effects of two Iranian Scorpions Odontobuthusdoriae and Bothutus saulcyi on Five Human Cultured Cell lines and Fractions of Toxic Venom.

Iranian journal of pharmaceutical research : IJPR

Ahmad Salarian A, Jalali A, Zare Mirakabadi A, Vatanpour H, H Shirazi F.
PMID: 24250459
Iran J Pharm Res. 2012;11(1):357-67.

Scorpion venom toxicity is of major concern due to its influence on human activities and public health. We investigated the in-vitro process of cell death caused by two Iranian scorpions Odontobuthus doriae and Bothutus salceyi venom on human cell...

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Ahmad Salarian A, Jalali A, Zare Mirakabadi A, et al. Cytotoxic Effects of two Iranian Scorpions Odontobuthusdoriae and Bothutus saulcyi on Five Human Cultured Cell lines and Fractions of Toxic Venom. Iran J Pharm Res. 2012;11(1):357-67
Ahmad Salarian, A., Jalali, A., Zare Mirakabadi, A., Vatanpour, H., & H Shirazi, F. (2012). Cytotoxic Effects of two Iranian Scorpions Odontobuthusdoriae and Bothutus saulcyi on Five Human Cultured Cell lines and Fractions of Toxic Venom. Iranian journal of pharmaceutical research : IJPR, 11(1), 357-67.
Ahmad Salarian, Amir, et al. "Cytotoxic Effects of two Iranian Scorpions Odontobuthusdoriae and Bothutus saulcyi on Five Human Cultured Cell lines and Fractions of Toxic Venom." Iranian journal of pharmaceutical research : IJPR vol. 11,1 (2012): 357-67.
Ahmad Salarian A, Jalali A, Zare Mirakabadi A, Vatanpour H, H Shirazi F. Cytotoxic Effects of two Iranian Scorpions Odontobuthusdoriae and Bothutus saulcyi on Five Human Cultured Cell lines and Fractions of Toxic Venom. Iran J Pharm Res. 2012;11(1):357-67. PMID: 24250459; PMCID: PMC3813092.
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Imperatoxin A, a Cell-Penetrating Peptide from Scorpion Venom, as a Probe of Ca-Release Channels/Ryanodine Receptors.

Pharmaceuticals (Basel, Switzerland)

Gurrola GB, Capes EM, Zamudio FZ, Possani LD, Valdivia HH.
PMID: 20668646
Pharmaceuticals (Basel). 2010 Apr 01;3(4):1093-1107. doi: 10.3390/ph3041093.

Scorpion venoms are rich in ion channel-modifying peptides, which have proven to be invaluable probes of ion channel structure-function relationship. We previously isolated imperatoxin A (IpTxa), a 3.7 kDa peptide activator of Ca(2+)-release channels/ryanodine receptors (RyRs) [1,2,3] and founding...

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Gurrola GB, Capes EM, Zamudio FZ, et al. Imperatoxin A, a Cell-Penetrating Peptide from Scorpion Venom, as a Probe of Ca-Release Channels/Ryanodine Receptors. Pharmaceuticals (Basel). 2010;3(4):1093-1107doi: 10.3390/ph3041093.
Gurrola, G. B., Capes, E. M., Zamudio, F. Z., Possani, L. D., & Valdivia, H. H. (2010). Imperatoxin A, a Cell-Penetrating Peptide from Scorpion Venom, as a Probe of Ca-Release Channels/Ryanodine Receptors. Pharmaceuticals (Basel, Switzerland), 3(4), 1093-1107. https://doi.org/10.3390/ph3041093
Gurrola, Georgina B, et al. "Imperatoxin A, a Cell-Penetrating Peptide from Scorpion Venom, as a Probe of Ca-Release Channels/Ryanodine Receptors." Pharmaceuticals (Basel, Switzerland) vol. 3,4 (2010): 1093-1107. doi: https://doi.org/10.3390/ph3041093
Gurrola GB, Capes EM, Zamudio FZ, Possani LD, Valdivia HH. Imperatoxin A, a Cell-Penetrating Peptide from Scorpion Venom, as a Probe of Ca-Release Channels/Ryanodine Receptors. Pharmaceuticals (Basel). 2010 Apr 01;3(4):1093-1107. doi: 10.3390/ph3041093. PMID: 20668646; PMCID: PMC2910439.
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Sequence characterization of cDNA sequence of encoding of an antimicrobial Peptide with no disulfide bridge from the Iranian mesobuthus eupeus venomous glands.

Iranian Red Crescent medical journal

Farajzadeh-Sheikh A, Jolodar A, Ghaemmaghami S.
PMID: 23486842
Iran Red Crescent Med J. 2013 Jan;15(1):36-41. doi: 10.5812/ircmj.4024. Epub 2013 Jan 05.

BACKGROUND: Scorpion venom glands produce some antimicrobial peptides (AMP) that can rapidly kill a broad range of microbes and have additional activities that impact on the quality and effectiveness of innate responses and inflammation.OBJECTIVES: In this study, we reported...

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Farajzadeh-Sheikh A, Jolodar A, Ghaemmaghami S. Sequence characterization of cDNA sequence of encoding of an antimicrobial Peptide with no disulfide bridge from the Iranian mesobuthus eupeus venomous glands. Iran Red Crescent Med J. 2013;15(1):36-41doi: 10.5812/ircmj.4024.
Farajzadeh-Sheikh, A., Jolodar, A., & Ghaemmaghami, S. (2013). Sequence characterization of cDNA sequence of encoding of an antimicrobial Peptide with no disulfide bridge from the Iranian mesobuthus eupeus venomous glands. Iranian Red Crescent medical journal, 15(1), 36-41. https://doi.org/10.5812/ircmj.4024
Farajzadeh-Sheikh, Ahmad, et al. "Sequence characterization of cDNA sequence of encoding of an antimicrobial Peptide with no disulfide bridge from the Iranian mesobuthus eupeus venomous glands." Iranian Red Crescent medical journal vol. 15,1 (2013): 36-41. doi: https://doi.org/10.5812/ircmj.4024
Farajzadeh-Sheikh A, Jolodar A, Ghaemmaghami S. Sequence characterization of cDNA sequence of encoding of an antimicrobial Peptide with no disulfide bridge from the Iranian mesobuthus eupeus venomous glands. Iran Red Crescent Med J. 2013 Jan;15(1):36-41. doi: 10.5812/ircmj.4024. Epub 2013 Jan 05. PMID: 23486842; PMCID: PMC3589777.
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Mass landscapes of seven scorpion species: The first analyses of Australian species with 1,5-DAN matrix.

Journal of venom research

Smith JJ, Jones A, Alewood PF.
PMID: 23236582
J Venom Res. 2012;3:7-14. Epub 2012 Oct 23.

Scorpion venoms have been studied for over fifty years; however, the majority of research has focussed primarily on medically important Buthidae species. Additionally, venoms of the estimated 200 species of scorpion native to Australia have received very little attention....

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Smith JJ, Jones A, Alewood PF. Mass landscapes of seven scorpion species: The first analyses of Australian species with 1,5-DAN matrix. J Venom Res. 2012;3:7-14
Smith, J. J., Jones, A., & Alewood, P. F. (2012). Mass landscapes of seven scorpion species: The first analyses of Australian species with 1,5-DAN matrix. Journal of venom research, 37-14.
Smith, Jennifer J, et al. "Mass landscapes of seven scorpion species: The first analyses of Australian species with 1,5-DAN matrix." Journal of venom research vol. 3 (2012): 7-14.
Smith JJ, Jones A, Alewood PF. Mass landscapes of seven scorpion species: The first analyses of Australian species with 1,5-DAN matrix. J Venom Res. 2012;3:7-14. Epub 2012 Oct 23. PMID: 23236582; PMCID: PMC3518322.
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Neurological and Systemic Manifestations of Severe Scorpion Envenomation.

Cureus

Godoy DA, Badenes R, Seifi S, Salehi S, Seifi A.
PMID: 34055554
Cureus. 2021 Apr 27;13(4):e14715. doi: 10.7759/cureus.14715.

Scorpion envenomation is a life-threatening toxicological emergency and considered as a major public health problem, especially in endemic regions (India, Africa, Latin America); it is generally characterized by low resources and tropical or subtropical weather. Scorpion envenomation is especially...

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Godoy DA, Badenes R, Seifi S, et al. Neurological and Systemic Manifestations of Severe Scorpion Envenomation. Cureus. 2021;13(4):e14715doi: 10.7759/cureus.14715.
Godoy, D. A., Badenes, R., Seifi, S., Salehi, S., & Seifi, A. (2021). Neurological and Systemic Manifestations of Severe Scorpion Envenomation. Cureus, 13(4), e14715. https://doi.org/10.7759/cureus.14715
Godoy, Daniel A, et al. "Neurological and Systemic Manifestations of Severe Scorpion Envenomation." Cureus vol. 13,4 (2021): e14715. doi: https://doi.org/10.7759/cureus.14715
Godoy DA, Badenes R, Seifi S, Salehi S, Seifi A. Neurological and Systemic Manifestations of Severe Scorpion Envenomation. Cureus. 2021 Apr 27;13(4):e14715. doi: 10.7759/cureus.14715. PMID: 34055554; PMCID: PMC8158070.
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A non-lethal method for studying scorpion venom gland transcriptomes, with a review of potentially suitable taxa to which it can be applied.

PloS one

Vonk FJ, Bittenbinder MA, Kerkkamp HMI, Grashof DGB, Archer JP, Afonso S, Richardson MK, Kool J, van der Meijden A.
PMID: 34793470
PLoS One. 2021 Nov 18;16(11):e0258712. doi: 10.1371/journal.pone.0258712. eCollection 2021.

Scorpion venoms are mixtures of proteins, peptides and small molecular compounds with high specificity for ion channels and are therefore considered to be promising candidates in the venoms-to-drugs pipeline. Transcriptomes are important tools for studying the composition and expression...

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Vonk FJ, Bittenbinder MA, Kerkkamp HMI, et al. A non-lethal method for studying scorpion venom gland transcriptomes, with a review of potentially suitable taxa to which it can be applied. PLoS One. 2021;16(11):e0258712doi: 10.1371/journal.pone.0258712.
Vonk, F. J., Bittenbinder, M. A., Kerkkamp, H. M. I., Grashof, D. G. B., Archer, J. P., Afonso, S., Richardson, M. K., Kool, J., & van der Meijden, A. (2021). A non-lethal method for studying scorpion venom gland transcriptomes, with a review of potentially suitable taxa to which it can be applied. PloS one, 16(11), e0258712. https://doi.org/10.1371/journal.pone.0258712
Vonk, Freek J, et al. "A non-lethal method for studying scorpion venom gland transcriptomes, with a review of potentially suitable taxa to which it can be applied." PloS one vol. 16,11 (2021): e0258712. doi: https://doi.org/10.1371/journal.pone.0258712
Vonk FJ, Bittenbinder MA, Kerkkamp HMI, Grashof DGB, Archer JP, Afonso S, Richardson MK, Kool J, van der Meijden A. A non-lethal method for studying scorpion venom gland transcriptomes, with a review of potentially suitable taxa to which it can be applied. PLoS One. 2021 Nov 18;16(11):e0258712. doi: 10.1371/journal.pone.0258712. eCollection 2021. PMID: 34793470; PMCID: PMC8601437.
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Mass spectrometry-based top-down and bottom-up approaches for proteomic analysis of the Moroccan Buthus occitanus scorpion venom.

FEBS open bio

Daoudi K, Malosse C, Lafnoune A, Darkaoui B, Chakir S, Sabatier JM, Chamot-Rooke J, Cadi R, Oukkache N.
PMID: 33715301
FEBS Open Bio. 2021 Jul;11(7):1867-1892. doi: 10.1002/2211-5463.13143. Epub 2021 May 28.

Buthus occitanus (B. occitanus) is one of the most dangerous scorpions in the world. Despite the involvement of B. occitanus scorpion in severe cases of envenomation in Morocco, no study has focused yet on the proteomic composition of the...

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Daoudi K, Malosse C, Lafnoune A, et al. Mass spectrometry-based top-down and bottom-up approaches for proteomic analysis of the Moroccan Buthus occitanus scorpion venom. FEBS Open Bio. 2021;11(7):1867-1892doi: 10.1002/2211-5463.13143.
Daoudi, K., Malosse, C., Lafnoune, A., Darkaoui, B., Chakir, S., Sabatier, J. M., Chamot-Rooke, J., Cadi, R., & Oukkache, N. (2021). Mass spectrometry-based top-down and bottom-up approaches for proteomic analysis of the Moroccan Buthus occitanus scorpion venom. FEBS open bio, 11(7), 1867-1892. https://doi.org/10.1002/2211-5463.13143
Daoudi, Khadija, et al. "Mass spectrometry-based top-down and bottom-up approaches for proteomic analysis of the Moroccan Buthus occitanus scorpion venom." FEBS open bio vol. 11,7 (2021): 1867-1892. doi: https://doi.org/10.1002/2211-5463.13143
Daoudi K, Malosse C, Lafnoune A, Darkaoui B, Chakir S, Sabatier JM, Chamot-Rooke J, Cadi R, Oukkache N. Mass spectrometry-based top-down and bottom-up approaches for proteomic analysis of the Moroccan Buthus occitanus scorpion venom. FEBS Open Bio. 2021 Jul;11(7):1867-1892. doi: 10.1002/2211-5463.13143. Epub 2021 May 28. PMID: 33715301; PMCID: PMC8255848.
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Characterization of Leiurus abdullahbayrami (Scorpiones: Buthidae) venom: peptide profile, cytotoxicity and antimicrobial activity.

The journal of venomous animals and toxins including tropical diseases

Erdeş E, Doğan TS, Coşar I, Danışman T, Kunt KB, Seker T, Yücel M, Ozen C.
PMID: 25414725
J Venom Anim Toxins Incl Trop Dis. 2014 Nov 03;20(1):48. doi: 10.1186/1678-9199-20-48. eCollection 2014.

BACKGROUND: Scorpion venoms are rich bioactive peptide libraries that offer promising molecules that may lead to the discovery and development of new drugs. Leiurus abdullahbayrami produces one of the most potent venoms among Turkish scorpions that provokes severe symptoms...

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Erdeş E, Doğan TS, Coşar I, et al. Characterization of Leiurus abdullahbayrami (Scorpiones: Buthidae) venom: peptide profile, cytotoxicity and antimicrobial activity. J Venom Anim Toxins Incl Trop Dis. 2014;20(1):48doi: 10.1186/1678-9199-20-48.
Erdeş, E., Doğan, T. S., Coşar, I., Danışman, T., Kunt, K. B., Seker, T., Yücel, M., & Ozen, C. (2014). Characterization of Leiurus abdullahbayrami (Scorpiones: Buthidae) venom: peptide profile, cytotoxicity and antimicrobial activity. The journal of venomous animals and toxins including tropical diseases, 20(1), 48. https://doi.org/10.1186/1678-9199-20-48
Erdeş, Efe, et al. "Characterization of Leiurus abdullahbayrami (Scorpiones: Buthidae) venom: peptide profile, cytotoxicity and antimicrobial activity." The journal of venomous animals and toxins including tropical diseases vol. 20,1 (2014): 48. doi: https://doi.org/10.1186/1678-9199-20-48
Erdeş E, Doğan TS, Coşar I, Danışman T, Kunt KB, Seker T, Yücel M, Ozen C. Characterization of Leiurus abdullahbayrami (Scorpiones: Buthidae) venom: peptide profile, cytotoxicity and antimicrobial activity. J Venom Anim Toxins Incl Trop Dis. 2014 Nov 03;20(1):48. doi: 10.1186/1678-9199-20-48. eCollection 2014. PMID: 25414725; PMCID: PMC4237746.
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Effects of Brazilian scorpion venoms on the central nervous system.

The journal of venomous animals and toxins including tropical diseases

Nencioni ALA, Neto EB, de Freitas LA, Dorce VAC.
PMID: 29410679
J Venom Anim Toxins Incl Trop Dis. 2018 Jan 23;24:3. doi: 10.1186/s40409-018-0139-x. eCollection 2018.

In Brazil, the scorpion species responsible for most severe incidents belong to the

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Nencioni ALA, Neto EB, de Freitas LA, et al. Effects of Brazilian scorpion venoms on the central nervous system. J Venom Anim Toxins Incl Trop Dis. 2018;24:3doi: 10.1186/s40409-018-0139-x.
Nencioni, A. L. A., Neto, E. B., de Freitas, L. A., & Dorce, V. A. C. (2018). Effects of Brazilian scorpion venoms on the central nervous system. The journal of venomous animals and toxins including tropical diseases, 243. https://doi.org/10.1186/s40409-018-0139-x
Nencioni, Ana Leonor Abrahão, et al. "Effects of Brazilian scorpion venoms on the central nervous system." The journal of venomous animals and toxins including tropical diseases vol. 24 (2018): 3. doi: https://doi.org/10.1186/s40409-018-0139-x
Nencioni ALA, Neto EB, de Freitas LA, Dorce VAC. Effects of Brazilian scorpion venoms on the central nervous system. J Venom Anim Toxins Incl Trop Dis. 2018 Jan 23;24:3. doi: 10.1186/s40409-018-0139-x. eCollection 2018. PMID: 29410679; PMCID: PMC5781280.
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Comparison between two methods of scorpion venom milking in Morocco.

The journal of venomous animals and toxins including tropical diseases

Oukkache N, Chgoury F, Lalaoui M, Cano AA, Ghalim N.
PMID: 23849043
J Venom Anim Toxins Incl Trop Dis. 2013 Mar 28;19(1):5. doi: 10.1186/1678-9199-19-5.

BACKGROUND: The present study compared two methods used successfully in a large-scale program for the collection of scorpion venoms, namely the milking of adult scorpions via manual and electrical stimulation.RESULTS: Our immunobiochemical characterizations clearly demonstrate that regularly applied electrical...

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Oukkache N, Chgoury F, Lalaoui M, et al. Comparison between two methods of scorpion venom milking in Morocco. J Venom Anim Toxins Incl Trop Dis. 2013;19(1):5doi: 10.1186/1678-9199-19-5.
Oukkache, N., Chgoury, F., Lalaoui, M., Cano, A. A., & Ghalim, N. (2013). Comparison between two methods of scorpion venom milking in Morocco. The journal of venomous animals and toxins including tropical diseases, 19(1), 5. https://doi.org/10.1186/1678-9199-19-5
Oukkache, Naoual, et al. "Comparison between two methods of scorpion venom milking in Morocco." The journal of venomous animals and toxins including tropical diseases vol. 19,1 (2013): 5. doi: https://doi.org/10.1186/1678-9199-19-5
Oukkache N, Chgoury F, Lalaoui M, Cano AA, Ghalim N. Comparison between two methods of scorpion venom milking in Morocco. J Venom Anim Toxins Incl Trop Dis. 2013 Mar 28;19(1):5. doi: 10.1186/1678-9199-19-5. PMID: 23849043; PMCID: PMC3707106.
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The unfulfilled promises of scorpion insectotoxins.

The journal of venomous animals and toxins including tropical diseases

Ortiz E, Possani LD.
PMID: 26085828
J Venom Anim Toxins Incl Trop Dis. 2015 Jun 17;21:16. doi: 10.1186/s40409-015-0019-6. eCollection 2015.

Since the description and biochemical characterization of the first insect-specific neurotoxins from scorpion venoms, almost all contributions have highlighted their potential application as leads for the development of potent bioinsecticides. Their practical use, however, has been hindered by different...

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Ortiz E, Possani LD. The unfulfilled promises of scorpion insectotoxins. J Venom Anim Toxins Incl Trop Dis. 2015;21:16doi: 10.1186/s40409-015-0019-6.
Ortiz, E., & Possani, L. D. (2015). The unfulfilled promises of scorpion insectotoxins. The journal of venomous animals and toxins including tropical diseases, 2116. https://doi.org/10.1186/s40409-015-0019-6
Ortiz, Ernesto, and Possani, Lourival D. "The unfulfilled promises of scorpion insectotoxins." The journal of venomous animals and toxins including tropical diseases vol. 21 (2015): 16. doi: https://doi.org/10.1186/s40409-015-0019-6
Ortiz E, Possani LD. The unfulfilled promises of scorpion insectotoxins. J Venom Anim Toxins Incl Trop Dis. 2015 Jun 17;21:16. doi: 10.1186/s40409-015-0019-6. eCollection 2015. PMID: 26085828; PMCID: PMC4470000.
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Showing 1 to 12 of 31 entries