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Characterization of forebrain neurons derived from late-onset Huntington's disease human embryonic stem cell lines.

Frontiers in cellular neuroscience

Niclis JC, Pinar A, Haynes JM, Alsanie W, Jenny R, Dottori M, Cram DS.
PMID: 23576953
Front Cell Neurosci. 2013 Apr 05;7:37. doi: 10.3389/fncel.2013.00037. eCollection 2013.

Huntington's disease (HD) is an incurable neurodegenerative disorder caused by a CAG repeat expansion in exon 1 of the Huntingtin (HTT) gene. Recently, induced pluripotent stem cell (iPSC) lines carrying atypical and aggressive (CAG60+) HD variants have been generated...

Next generation sequencing reveals skewing of the T and B cell receptor repertoires in patients with wiskott-Aldrich syndrome.

Frontiers in immunology

O'Connell AE, Volpi S, Dobbs K, Fiorini C, Tsitsikov E, de Boer H, Barlan IB, Despotovic JM, Espinosa-Rosales FJ, Hanson IC, Kanariou MG, Martínez-Beckerat R, Mayorga-Sirera A, Mejia-Carvajal C, Radwan N, Weiss AR, Pai SY, Lee YN, Notarangelo LD.
PMID: 25101082
Front Immunol. 2014 Jul 18;5:340. doi: 10.3389/fimmu.2014.00340. eCollection 2014.

The Wiskott-Aldrich syndrome (WAS) is due to mutations of the WAS gene encoding for the cytoskeletal WAS protein, leading to abnormal downstream signaling from the T cell and B cell antigen receptors (TCR and BCR). We hypothesized that the...

Inflammatory Cyclooxygenase Activity and PGE.

Current immunology reviews

Johansson JU, Woodling NS, Shi J, Andreasson KI.
PMID: 28413375
Curr Immunol Rev. 2015 Aug;11(2):125-131. doi: 10.2174/1573395511666150707181414.

The inflammatory response is a fundamental driving force in the pathogenesis of Alzheimer's disease (AD). In the setting of accumulating immunogenic Aß peptide assemblies, microglia, the innate immune cells of the brain, generate a non-resolving immune response and fail...

An UHPLC-MS/MS method for the simultaneous determination of ampicillin and sulbactam in human plasma and urine.


Parker SL, Adnan S, Ordóñez Meija JL, Paterson DL, Lipman J, Roberts JA, Wallis SC.
PMID: 26395242
Bioanalysis. 2015 Sep;7(18):2311-2319. doi: 10.4155/bio.15.143. Epub 2015 Sep 23.

BACKGROUND: With few new antibiotics available and an increased prevalence of multidrug-resistant bacteria, optimizing the effectiveness of currently available antibiotics and minimizing the potential for emerging resistance, through PK characterization, is of paramount importance.RESULTS: Inter- and intra-assay results for...

Preoperative imaging markers and PDZ-binding kinase tissue expression predict low-risk disease in endometrial hyperplasias and low grade cancers.


Berg A, Gulati A, Ytre-Hauge S, Fasmer KE, Mauland KK, Hoivik EA, Husby JA, Tangen IL, Trovik J, Halle MK, Stefansson I, Akslen LA, Woie K, Bjørge L, Salvesen HB, Salvesen ØO, Werner HMJ, Haldorsen IS, Krakstad C.
PMID: 28978135
Oncotarget. 2017 Jul 31;8(40):68530-68541. doi: 10.18632/oncotarget.19708. eCollection 2017 Sep 15.

PURPOSE: Distinguishing complex atypical hyperplasia (CAH) from grade 1 endometrioid endometrial cancer (EECG1) preoperatively may be valuable in order to prevent surgical overtreatment, particularly in patients wishing preserved fertility or in patients carrying increased risk of perioperative complications.MATERIAL AND...

Targeted Therapies for the Treatment of Pediatric Non-Hodgkin Lymphomas: Present and Future.

Pharmaceuticals (Basel, Switzerland)

Sorge CE, McDaniel JK, Xavier AC.
PMID: 27213405
Pharmaceuticals (Basel). 2016 May 19;9(2). doi: 10.3390/ph9020028.

Pediatric Non-Hodgkin Lymphomas (NHL) are a diverse group of malignancies and as such treatment can vary based on the different biological characteristics of each malignancy. Significant advancements are being made in the treatment and outcomes of this group of...

Theory of Inpatient Circadian Care (TICC): A Proposal for a Middle-Range Theory.

The open nursing journal

Camargo-Sanchez A, Niño CL, Sánchez L, Echeverri S, Gutiérrez DP, Duque AF, Pianeta O, Jaramillo-Gómez JA, Pilonieta MA, Cataño N, Arboleda H, Agostino PV, Alvarez-Baron CP, Vargas R.
PMID: 25767632
Open Nurs J. 2015 Feb 27;9:1-9. doi: 10.2174/1874434601509010001. eCollection 2015.

The circadian system controls the daily rhythms of a variety of physiological processes. Most organisms show physiological, metabolic and behavioral rhythms that are coupled to environmental signals. In humans, the main synchronizer is the light/dark cycle, although non-photic cues...

Decidual Cox2 inhibition improves fetal and maternal outcomes in a preeclampsia-like mouse model.

JCI insight

Sones JL, Cha J, Woods AK, Bartos A, Heyward CY, Lob HE, Isroff CE, Butler SD, Shapiro SE, Dey SK, Davisson RL.
PMID: 27159542
JCI Insight. 2016 Mar 17;1(3). doi: 10.1172/jci.insight.75351.

Preeclampsia (PE) is a disorder of pregnancy that manifests as late gestational maternal hypertension and proteinuria and can be life-threatening to both the mother and baby. It is believed that abnormal placentation is responsible for the cascade of events...

Obesity and Healthcare Avoidance: A Systematic Review.

AIMS public health

McGuigan RD, Wilkinson JM.
PMID: 29546095
AIMS Public Health. 2015 Mar 11;2(1):56-63. doi: 10.3934/publichealth.2015.1.56. eCollection 2015.

This review addresses the issue of health care avoidance and obesity. English language journal articles published between 1990 and 2012 that addressed the review question; "is being overweight or obese an unrecognized factor in healthcare avoidance?" were located using...

Bone Mineral Density in Postmenopausal Women Heterozygous for the C282Y HFE Mutation.

Journal of osteoporosis

Gunton JE, Gates F, Fulcher GR, Clifton-Bligh PB.
PMID: 27123357
J Osteoporos. 2016;2016:5638273. doi: 10.1155/2016/5638273. Epub 2016 Mar 31.

Mutations in the HFE gene may be associated with increased tissue iron stores reflected in an elevated serum ferritin. With homozygous mutation C282Y, the increase in serum ferritin may be associated with tissue damage in the liver, pancreas, and...

Discourse in Action: Parents' use of medical and social models to resist disability stigma.

Social science & medicine (1982)

Manago B, Davis JL, Goar C.
PMID: 28550803
Soc Sci Med. 2017 Jul;184:169-177. doi: 10.1016/j.socscimed.2017.05.015. Epub 2017 May 06.

For parents of children with disabilities, stigmatization is part of everyday life. To resist the negative social and emotional consequences of stigma, parents both challenge and deflect social devaluations. Challenges work to upend the stigmatizing structure, while deflections maintain...

Pustular psoriasis of pregnancy: current perspectives.

International journal of women's health

Trivedi MK, Vaughn AR, Murase JE.
PMID: 29520163
Int J Womens Health. 2018 Feb 26;10:109-115. doi: 10.2147/IJWH.S125784. eCollection 2018.

Pustular psoriasis of pregnancy (PPP) is a life-threatening condition for both the pregnant mother and fetus, and must be efficiently and accurately diagnosed and treated. This condition has historically been classified as a unique, separate dermatosis of pregnancy. However,...

Showing 1 to 12 of 1713 entries